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Prepaid expenses and other current assets

239,169

Accounts receivable

362,809

467,658

Other receivable

2,414

1,380

Inventory

2,328,520

2,072,817

365,335

497,373

Total current assets

10,867,402

3,799,095

Land, property and equipment, net

1,213,564

1,222,068

Goodwill

5,210,821

Intangible assets, net

32,975,555

33,397,222

Total assets

50,267,342

43,629,206

Current liabilities:

Accounts payable

3,162,179

7,354,932

Deferred collaboration revenue

177,389

Deferred rent

3,240

4,584

Accrued expenses

1,664,234

2,199,549

Warrant liability

192,960

103,860

15,000

11,000

111,841

690,683

2,672,215

Current portion of long-term debt

3,656,099

1,141,153

1,609,244

Total current liabilities

9,384,395

15,385,767

Convertible long-term debt, net of discount

10,875,300

10,982,437

Total liabilities

20,259,695

26,368,204

Commitments and Contingencies (See Note 7)

Series A convertible preferred stock: $0.0001 par value, 10,000,000 shares authorized at March 31, 2018 and December 31, 2017; 5,524,926 and 0 shares issued and outstanding at March 31, 2018 and December 31, 2017; (liquidation preference of $9,199,002 at March 31, 2018)

9,000,002

Stockholders' Equity:

Additional paid-in capital

89,092,172

79,655,191

Accumulated deficit

(68,101,359)

(62,404,722)

Total stockholders' equity

21,007,645

17,261,002

Total liabilities, convertible preferred stock and stockholders' equity

50,267,342

43,629,206

Common stock - voting

Stockholders' Equity:

Common stock value

12,570

6,271

Common stock - non-voting

Stockholders' Equity:

Common stock value

$ 4,262

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Convertible preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Convertible preferred stock, shares authorized	10,000,000	10,000,000
Convertible preferred stock, shares issued	5,524,926	0
Convertible preferred stock, shares outstanding	5,524,926	0
Liquidation preference value	$ 9,199,002
Common Stock \| Common stock - voting
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized	500,000,000	250,000,000
Common stock, shares issued	125,698,191	62,707,480
Common stock, shares outstanding	125,698,191	62,707,480
Common Stock \| Common stock - non-voting
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized	50,000,000	50,000,000
Common stock, shares issued	42,617,893	42,617,893
Common stock, shares outstanding	42,617,893	42,617,893

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue
Total revenue	$ 804,356	$ 822,410
Operating Expenses
Cost of product revenue	464,161	16,145
Research and development expense	757,866	1,255,452
Sales and marketing expense	1,712,190	122,912
General and administrative expense	2,998,400	3,303,503
Total operating expenses	5,932,617	4,698,012
Loss from operations	(5,128,261)	(3,875,602)
Interest expense	(602,022)	(180,072)
Other income	297,500	1,448
Change in fair value of warrants and conversion option liability	(263,854)	(453,419)
Loss on extinguishment of debt		(207,713)
Net loss and comprehensive loss	(5,696,637)	(4,715,358)
Deemed dividend attributable to preferred stock	(995,000)
Net loss attributable to common shareholders	$ (6,691,637)	$ (4,715,358)
Net loss per share, basic and diluted (in dollars per share)	$ (0.05)	$ (0.33)
Weighted-average common shares outstanding, basic and diluted (in shares)	129,467,132	14,157,351
Product revenue
Revenue
Total revenue	$ 626,967	$ 74,544
Collaboration revenue
Revenue
Total revenue	$ 177,389	$ 747,866

CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN COMMON STOCK, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (DEFICIT) - USD ($)

Private Investment in Public Entities June 2016

Common Stock

Common stock - voting

Private Investment in Public Entities June 2016

Additional Paid-in Capital

Private Investment in Public Entities June 2016

Private Investment in Public Entities

Common Stock

Common stock - voting

Private Investment in Public Entities

Additional Paid-in Capital

Private Investment in Public Entities

Private Investment in Public Entities June 2017

Common Stock

Common stock - voting

Private Investment in Public Entities June 2017

Additional Paid-in Capital

Private Investment in Public Entities June 2017

Private Investment in Public Entities November 2017

Common Stock

Common stock - voting

Private Investment in Public Entities November 2017

Additional Paid-in Capital

Private Investment in Public Entities November 2017

Private Investment in Public Entities January 2018

Common Stock

Common stock - voting

Private Investment in Public Entities January 2018

Additional Paid-in Capital

Private Investment in Public Entities January 2018

Private Investment in Public Entities March 2018

Common Stock

Common stock - voting

Private Investment in Public Entities March 2018

Additional Paid-in Capital

Private Investment in Public Entities March 2018

Series A Convertible Preferred Stock

Private Investment in Public Entities March 2018

Common Stock

Common stock - voting

Common Stock

Common stock - non-voting

Additional Paid-in Capital

Common stock - voting

Additional Paid-in Capital

Common stock - non-voting

Additional Paid-in Capital

Accumulated deficit

Series A Convertible Preferred Stock

Common stock - voting

Common stock - non-voting

Total

Balance at Dec. 31, 2016

$ 1,401

$ 37,980,522

$ (40,436,108)

$ (2,454,185)

Balance (in shares) at Dec. 31, 2016

14,007,132

Increase (decrease) in Stockholders' Equity (Deficit)

Issuance of common stock in a private investment in public entities offering, net of offering costs of $72,710 and $6,000

$ 397

$ 2,313,977

$ 2,314,374

$ 20

$ 93,980

$ 94,000

Issuance of common stock in a private investment in public entities offering, net of offering costs of $72,710 and $6,000 (in shares)

3,972,510

200,000

Issuance of common stock through a stock purchase agreement with a private investor, net of offering costs of $44,738 November 2017

$ 510

$ 554,752

$ 555,262

Issuance of common stock through a stock purchase agreement with a private investor, net of offering costs of $44,738 November 2017 (in shares)

5,100,000

Issuance of common stock

$ 401

$ 400,599

$ 401,000

$ 325

2,999,675

3,000,000

Issuance of common stock (in shares)

4,010,000

3,243,243

Issuance of common stock in a merger

$ 228

$ 4,317

$ 1,277,941

$ 24,172,725

$ 1,278,169

$ 24,177,042

Issuance of common stock in the merger (in shares)

2,282,445

43,173,288

Issuance of common stock in a follow-on offering registration statement October 2017, net of commissions and offering costs of $763,502

$ 2,169

3,571,829

3,573,998

Issuance of common stock in a follow-on offering registration statement October 2017, net of commissions and offering costs of $763,502 (in shares)

21,687,500

Conversion of non-voting common stock to common stock

$ 55

$ (55)

Conversion of non-voting common stock to common stock (in shares)

555,395

(555,395)

Issuance of warrants in the merger

630,859

Issuance of stock options in the merger

5,691

Issuance of RSUs in the merger

3,300,555

Issuance of common stock in exchange of warrants

$ 91

386,243

386,334

Issuance of common stock in exchange of warrants (in shares)

908,334

Stock-based compensation

814,613

Warrants, issued in conjunction with debt extinguishment

207,713

Issuance of common stock in exchange for vested restricted stock units

$ 1

(1)

Issuance of common stock in exchange for vested restricted stock units (in shares)

13,703

Issuance of common stock in exchange for redemption of convertible debt

$ 649

899,713

900,362

Issuance of common stock in exchange for redemption of convertible debt (in shares)

6,492,084

Issuance of common stock in exchange for services

$ 24

43,805

43,829

Issuance of common stock in exchange for services (in shares)

235,134

Net and comprehensive loss

(21,968,614)

Balance at Dec. 31, 2017

$ 6,271

$ 4,262

79,655,191

(62,404,722)

17,261,002

^[1]

Ending Balance at Dec. 31, 2017

^[1]

Balance (in shares) at Dec. 31, 2017

62,707,480

42,617,893

Increase (decrease) in Stockholders' Equity (Deficit)

Issuance of preferred stock and common stock in a private investment in public entities

$ 2,940

$ 4,997,060

$ 9,000,002

$ 5,000,000

Issuance of preferred stock and common stock in a private investment in public entities (in shares)

29,411,766

5,524,926

Beneficial conversion feature of the series A convertible preferred stock

995,000

$ (995,000)

995,000

Deemed dividend on Series A convertible preferred stock

(995,000)

995,000

(995,000)

Issuance of common stock in a private investment in public entities offering, net of offering costs of $72,710 and $6,000

$ 975

$ 1,304,799

$ 1,305,774

$ 718

$ 749,382

$ 750,100

Issuance of common stock in a private investment in public entities offering, net of offering costs of $72,710 and $6,000 (in shares)

9,746,413

7,182,818

Stock-based compensation

272,243

Issuance of common stock in exchange for redemption of convertible debt

$ 1,232

1,402,781

1,404,013

Issuance of common stock in exchange for redemption of convertible debt (in shares)

12,314,291

Issuance of common stock in exchange for services

$ 5

6,420

6,425

Issuance of common stock in exchange for services (in shares)

50,000

Issuance of common stock in exchange for payment of interest expense

$ 429

704,296

704,725

Issuance of common stock in exchange for payment of interest expense (in shares)

4,285,423

Net and comprehensive loss

(5,696,637)

Balance at Mar. 31, 2018

$ 12,570

$ 4,262

$ 89,092,172

$ (68,101,359)

21,007,645

Ending Balance at Mar. 31, 2018

$ 9,000,002

Balance (in shares) at Mar. 31, 2018

125,698,191

42,617,893

5,524,926

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN COMMON STOCK, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (DEFICIT) (Parenthetical) - Common Stock	12 Months Ended
	Dec. 31, 2017 USD ($)
Private Investment in Public Entities June 2016
Stock Transactions, Parenthetical Disclosures
Offering costs	$ 72,710
Private Investment in Public Entities June 2017
Stock Transactions, Parenthetical Disclosures
Offering costs	6,000
Stock Purchase Agreement with Private Investor November 2017
Stock Transactions, Parenthetical Disclosures
Offering costs	44,738
Follow-on Offering Registration October 2017
Stock Transactions, Parenthetical Disclosures
Offering costs	$ 763,502

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Cash Flows from Operating Activities
Net loss	$ (5,696,637)	$ (4,715,358)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	329,561	15,031
Interest paid on the conversion of debt to equity	20,496
Common stock issued in exchange for services rendered	6,425
Loss on extinguishment of debt		207,713
Stock-based compensation	272,243	228,036
Amortization of debt issuance costs and debt discount	403,824	96,772
Change in fair value of warrants and conversion option liability	263,854	453,419
Change in fair value of derivative liability	4,000
Changes in assets and liabilities
Accounts receivable	104,849	4,963
Other receivable	(1,034)	(288,166)
Inventory	(255,703)	20,114
Prepaid expenses and other current assets	132,038	(85,218)
Deferred offering costs		7,632
Due from former parent		78,226
Deferred collaboration revenue	(177,389)	2,088,989
Deferred product revenue		(16,196)
Deferred rent	(1,344)	158
Accounts payable	(4,192,753)	931,340
Accrued expenses	(834,123)	683,825
Total cash used in operations	(9,621,693)	(288,720)
Cash Flows from Investing Activities
Purchase of equipment	(6,527)
Total cash used in investing activities	(6,527)
Cash Flows from Financing Activities
Proceeds from issuance of long-term debt	2,310,000
Repayment of long-term debt	(1,689,199)	(490,101)
Proceeds from issuance of common stock through a stock purchase agreement with a private investor November 2017	1,305,774
Total Cash Provided by Financing Activities	16,676,677	52,701
Net decrease in cash, cash equivalents and restricted cash	7,048,457	(236,019)
Cash, cash equivalents and restricted cash at beginning of period	759,867	1,462,272
Cash, cash equivalents and restricted cash at end of period	7,808,324	1,226,253
Supplemental Schedule of Non-Cash Financing and Investing Activities
Interest paid on long-term debt	19,344
Deemed dividend attributable to preferred stock	995,000
Private Investment in Public Entities June 2016
Cash Flows from Financing Activities
Proceeds from issuance of common stock in a private investment in public entities		550,434
Deferred offering costs		$ (7,632)
Private Investment in Public Entities December 2017
Cash Flows from Financing Activities
Proceeds from issuance of common stock in a private investment in public entities	750,100
Private Investment in Public Entities March 2018
Cash Flows from Financing Activities
Proceeds from issuance of common stock in a private investment in public entities	5,000,000
Proceeds from the issuance of convertible preferred stock in private investment in public entities	9,199,002
Issuance costs associated with the issuance of convertible preferred stock in private investment in public entities	(199,000)
Jaguar Notes Payable
Supplemental Schedule of Non-Cash Financing and Investing Activities
Common stock issued as redemption of notes payable and related interest	950,000
Napo convertible notes
Supplemental Schedule of Non-Cash Financing and Investing Activities
Common stock issued as redemption of notes payable and related interest	$ 1,158,308

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Parenthetical) - USD ($)

Mar. 31, 2018

Dec. 31, 2017

Mar. 31, 2017

Dec. 31, 2016

Cash, Cash Equivalents and Restricted Cash:

Cash and cash equivalents

$ 7,808,324

$ 520,698

^[1]

$ 1,205,061

Total cash, cash equivalents and restricted cash

239,169

^[1]

21,192

$ 7,808,324

$ 759,867

$ 1,226,253

$ 1,462,272

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Organization and Business	3 Months Ended
Organization and Business	Mar. 31, 2018
Organization and Business
Organization and Business	1. Organization and Business Jaguar Health, Inc. (“Jaguar” or the “Company”), formerly known as Jaguar Animal Health, Inc., was incorporated on June 6, 2013 (inception) in Delaware. The Company was a majority-owned subsidiary of Napo Pharmaceuticals, Inc. (“Napo” or the “Former Parent”) until the close of the Company’s initial public offering on May 18, 2015. The Company was formed to develop and commercialize first-in-class gastrointestinal products for companion and production animals and horses. The Company’s first commercial product, Neonorm Calf, was launched in 2014 and Neonorm Foal was launched in the first quarter of 2016. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding in order to timely compete the development and commercialization of products. The Company manages its operations through two segments—human health and animal health and is headquartered in San Francisco, California. On June 11, 2013, Jaguar issued 2,666,666 shares of common stock to Napo in exchange for cash and services. On July 1, 2013, Jaguar entered into an employee leasing and overhead agreement (the “Service Agreement”) with Napo, under which Napo agreed to provide the Company with the services of certain Napo employees for research and development and the general administrative functions of the Company. See Note 9 for additional information regarding the capital contributions and Note 5 for the Service Agreement and license agreement details. Effective July 1, 2016, Napo agreed to reimburse the Company for the use of the Company’s employee’s time and related expenses, including rent and a fixed overhead amount to cover office supplies and copier use (Note 5). On July 31, 2017, Jaguar completed a merger with Napo pursuant to the Agreement and Plan of Merger dated March 31, 2017 by and among Jaguar, Napo, Napo Acquisition Corporation (“Merger Sub”), and Napo’s representative (the “Merger Agreement”). In accordance with the terms of the Merger Agreement, upon the completion of the merger, Merger Sub merged with and into Napo, with Napo surviving as our wholly-owned subsidiary (the “Merger” or “Napo Merger”). Immediately following the Merger, Jaguar changed its name from “Jaguar Animal Health, Inc.” to “Jaguar Health, Inc.” Napo now operates as a wholly-owned subsidiary of Jaguar focused on human health and the ongoing commercialization of Mytesi, a Napo drug product approved by the U.S. FDA for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy. The Company manages its operations through two segments—human health and animal health and is headquartered in San Francisco, California. Liquidity The accompanying consolidated financial statements have been prepared assuming the Company will continue as a going concern. The Company has incurred recurring operating losses since inception and has an accumulated deficit of $68,101,359 as of March 31, 2018. The Company expects to incur substantial losses in future periods. Further, the Company’s future operations are dependent on the success of the Company’s ongoing development and commercialization efforts, as well as the securing of additional financing. There is no assurance that profitable operations, if ever achieved, could be sustained on a continuing basis. The Company plans to finance its operations and capital funding needs through equity and/or debt financing, collaboration arrangements with other entities, as well as revenue from future product sales. However, there can be no assurance that additional funding will be available to the Company on acceptable terms on a timely basis, if at all, or that the Company will generate sufficient cash from operations to adequately fund operating needs or ultimately achieve profitability. If the Company is unable to obtain an adequate level of financing needed for the long-term development and commercialization of its products, the Company will need to curtail planned activities and reduce costs. Doing so will likely have an adverse effect on the Company’s ability to execute on its business plan. These matters raise substantial doubt about the ability of the Company to continue in existence as a going concern within one year after issuance date of the financial statements. The accompanying financial statements do not include any adjustments that might result from the outcome of these uncertainties. In June 2016, the Company entered into a common stock purchase agreement with a private investor (the “CSPA”), which provides that, upon the terms and subject to the conditions and limitations set forth therein, the investor is committed to purchase up to an aggregate of $15.0 million of the Company’s common stock over the approximately 30-month term of the agreement. Through March 31, 2018 the Company sold 6,000,000 shares for gross cash proceeds of $5,063,785. The CSPA limited the number of shares that the Company can sell thereunder to 2,027,490 shares, which equals 19.99% of the Company’s outstanding shares as of the date of the CSPA (such limit, the “19.99% exchange cap”), unless either (i) the Company obtains stockholder approval to issue more than such 19.99% exchange cap or (ii) the average price paid for all shares of the Company’s common stock issued under the CSPA is equal to or greater than $1.32 per share (the closing price on the date the CSPA was signed), in either case in compliance with Nasdaq Listing Rule 5635(d). At the 2017 Annual Stockholders’ Meeting on May 8, 2017, the Company’s stockholders voted on the approval, pursuant to Nasdaq Listing Rule 5635(d), of the issuance of an additional 3,555,514 shares of the Company’s common stock under the CSPA, which when combined with the 2,444,486 shares that the Company has already sold pursuant to the CSPA, equals an aggregate of 6,000,000 shares.

Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2018

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

Basis of Presentation

The financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) and applicable rules and regulations of the Securities and Exchange Commission (“SEC”). Our unaudited condensed financial statements reflect all adjustments, which are, in the opinion of management, necessary for a fair presentation of our financial position and results of operations. Such adjustments are of a normal recurring nature, unless otherwise noted. The balance sheet as of March 31, 2018 and the results of operations for the three months ended March 31, 2018 are not necessarily indicative of the results to be expected for the entire year.

Principles of Consolidation

The consolidated financial statements have been prepared in accordance with US GAAP and applicable rules and regulations of the Securities and Exchange Commission (“SEC”) and include the accounts of the Company and its wholly owned subsidiaries. All inter-company transactions and balances have been eliminated in consolidation.

Use of Estimates

The preparation of financial statements in conformity with U.S. GAAP requires the Company’s management to make judgments, assumptions and estimates that affect the amounts reported in its financial statements and the accompanying notes. The accounting policies that reflect the Company’s more significant estimates and judgments and that the Company believes are the most critical to aid in fully understanding and evaluating its reported financial results are valuation of stock options; valuation of warrant liabilities; valuation of derivative liability, impairment testing of goodwill, IPR&D, and long lived assets; useful lives for depreciation and amortization; valuation adjustments for excess and obsolete inventory; allowance for doubtful accounts; deferred taxes and valuation allowances on deferred tax assets; evaluation and measurement of contingencies; and recognition of revenue, including estimates for product returns. Those estimates could change, and as a result, actual results could differ materially from those estimates.

Concentration of Credit Risk and Cash and Cash Equivalents

Cash is the financial instrument that potentially subjects the Company to a concentration of credit risk as cash is deposited with a bank and cash balances are generally in excess of Federal Deposit Insurance Corporation insurance limits. The carrying value of cash approximates fair value at March 31, 2018 and December 31, 2017.

Fair Values

The Company’s financial instruments include, cash and cash equivalents, accounts receivable, accounts payable, accrued expenses, warrant liabilities, derivative liability, debt conversion option liability, and debt. Cash is reported at fair value. The recorded carrying amount of accounts receivable, accounts payable and accrued expenses reflect their fair value due to their short-term nature. The carrying value of the interest-bearing debt approximates fair value based upon the borrowing rates currently available to the Company for bank loans with similar terms and maturities. See Note 4 for the fair value measurements, and Note 8 for the fair value of the Company’s warrant liabilities, derivative liability, and debt conversion option liability.

Restricted Cash

On August 18, 2015, the Company entered into a long-term loan and security agreement with a lender for up to $8.0 million, which, along with subsequent loan amendments, required the Company to maintain a base minimum cash balance of varying amounts. The restricted cash balance related to the loan was $0 and $239,169 at March 31, 2018 and December 31, 2017, respectively.

Inventories

Inventories are stated at the lower of cost or net realizeable value. The Company calculates inventory valuation adjustments when conditions indicate that market is less than cost due to physical deterioration, usage, obsolescence, reductions in estimated future demand or reduction in selling price. Inventory write-downs are measured as the difference between the cost of inventory and net realizeable value.

Land, Property and Equipment

Land is stated at cost, reflecting fair value of the property at July 31, 2017, the date of the merger with Napo.

Equipment and furniture and fixtures are stated at cost, less accumulated depreciation. Equipment begins to be depreciated when it is placed into service. Depreciation is calculated using the straight-line method over the estimated useful lives of 3 to 10 years.

Expenditures for repairs and maintenance of assets are charged to expense as incurred. Costs of major additions and betterments are capitalized and depreciated on a straight-line basis over their estimated useful lives. Upon retirement or sale, the cost and related accumulated depreciation of assets disposed of are removed from the accounts and any resulting gain or loss is included in the statements of operations and comprehensive loss.

Long-Lived Assets

The Company regularly reviews the carrying value and estimated lives of all of its long-lived assets, including property and equipment to determine whether indicators of impairment may exist that warrant adjustments to carrying values or estimated useful lives. The determinants used for this evaluation include management’s estimate of the asset’s ability to generate positive income from operations and positive cash flow in future periods as well as the strategic significance of the assets to the Company’s business objectives.

Definite-lived intangible assets are amortized on a straight-line basis over the estimated periods benefited, and are reviewed regularly for possible impairment.

Goodwill and Indefinite-lived Intangible Assets

Goodwill is tested for impairment on an annual basis and in between annual tests if events or circumstances indicate that an impairment loss may have occurred. The test is based on a comparison of the reporting unit’s book value to its estimated fair market value. The Company performs annual impairment test during the fourth quarter of each fiscal year using the opening consolidated balance sheet as of the first day of the fourth quarter, with any resulting impairment recorded in the fourth quarter of the fiscal year.

If the carrying value of a reporting unit’s net assets exceeds its fair value, the goodwill would be considered impaired and would be reduced to its fair value. The goodwill was entirely allocated to the human health reporting unit as the goodwill relates to the Napo Merger. The decline in market capitalization during the year ended December 31, 2017 was determined to be a triggering event for potential goodwill impairment. Accordingly the Company performed the goodwill impairment analysis. The Company utilized the market capitalization plus a reasonable control premium in the performance of its impairment test. The market capitalization was based on the outstanding shares and the average market share price for the 30 days prior to December 31, 2017. Based on the results of the Company’s impairment test, the Company recorded an impairment charge of $16,827,000 during the year ended December 31, 2017. If the market capitalization decreases in the future, a reasonable possibility exists that goodwill could be further impaired in the near term and that such impairment may be material to the financial statements.

Fair value determinations require considerable judgment and are sensitive to changes in underlying assumptions, estimates and market factors. Estimating the fair value of individual reporting units and indefinite-lived intangible assets requires us to make assumptions and estimates regarding our future plans, as well as industry and economic conditions. These assumptions and estimates include projected revenues and income growth rates, terminal growth rates, competitive and consumer trends, market-based discount rates, and other market factors. If current expectations of future growth rates are not met or market factors outside of our control, such as discount rates, change significantly, this may lead to a further goodwill impairment in the future. Acquired in-process research and development (IPR&D) are intangible assets initially recognized at fair value and classified as indefinite-lived assets until the successful completion or abandonment of the associated research and development efforts. During the development period, these assets will not be amortized as charges to earnings; instead these assets will be tested for impairment on an annual basis or more frequently if impairment indicators are identified. We booked an impairment of $2,300,000 in the year ended December 31, 2017. The impairment loss is measured based on the excess of the carrying amount over the asset’s fair value. The loss resulted from the Company’s termination of the clostridium dificil infection program.

Additionally, as goodwill and intangible assets associated with recently acquired businesses are recorded on the balance sheet at their estimated acquisition date fair values, those amounts are more susceptible to an impairment risk if business operating results or macroeconomic conditions deteriorate.

In connection with each annual impairment assessment and any interim impairment assessment in which indicators of impairment have been identified, the Company compares the fair value of the asset as of the date of the assessment with the carrying value of the asset on the consolidated balance sheet. If impairment is indicated by this test, the intangible asset is written down by the amount by which the discounted cash flows expected from the intangible asset exceeds its carrying value.

Research and Development Expense

Research and development expense consists of expenses incurred in performing research and development activities including related salaries, clinical trial and related drug and non-drug product costs, contract services and other outside service expenses. Research and development expense is charged to operating expense in the period incurred.

Revenue Recognition

The Company recognizes revenue in accordance with ASC Topic 606, Revenue from Contracts with Customers (“ASC 606”), which was adopted on January 1, 2018, using the modified retrospective method, which was elected to apply to all contracts. Application of the modified retrospective method did not impact amounts previously reported by the Company, nor did it require a cumulative effect adjustment upon adoption, as the Company’s method of recognizing revenue under ASC 606 was similar to the method utilized immediately prior to adoption. Accordingly, there is no need for the Company to dislose the amount by which each financial statement line item was affected as a result of applying the new revenue standard and an explanation of significant changes.

The Company recognizes revenue in accordance with the core principal of ASC 606 or when there is a transfer of promised goods or services to customers in an amount that reflects the consideration that the Company expects to be entitled to in exchange for those goods or services.

Contracts

Napo has a Marketing and Distribution Agreement (“M&D Agreement”) with BexR Logistix, LLC (“BexR” or “Mission Pharmacal” or “Mission”), in April 2016 to appoint BexR as its distributor with the right to market and sell, and the exclusive right to distribute Mytesi (formerly Fulyzaq) in US. The term of the M&D Agreement is 4 years. The M&D Agreement will renew automatically for successive one year terms unless either party provides a written notice of termination not less than 90 days prior to the expiration of the initial or subsequent terms. Napo retains control of Mytesi held at Mission.

Napo sells Mytesi through Mission, who then sells Mytesi to its distributors and wholesalers — McKesson, Cardinal Health, AmerisourceBergen Drug Corporation (“ABC”), HD Smith, Smith Drug and Publix (together “Distributors”). Mission sells Mytesi to their Distributors, on behalf of Napo, under agreements executed by Mission with these Distributors and Napo abides by the terms and conditions of sales agreed between Mission and their Distributors. Health care providers order Mytesi through pharmacies who obtain Mytesi through Mission’s Distributors. Napo considers the Distributors of Mission as its customers.

Mission’s Distributors are the customers of the Company with respect to purchase of Mytesi. The M&D Agreement with Mission, Mission’s agreement with its Distributors and the related purchase order will together meet the contract existence criteria under ASC 606-10-25-1.

Jaguar’s Neonorm and Botanical extract products are primarily sold to distributors, who then sell the products to the end customers. Since 2014, the Company has entered into several distribution agreements with established distributors such as Animart, Vedco, VPI, RJ Matthews, Henry Schein, and Stockmen Supply to distribute the Company’s products in the United States, Japan, and China. The distribution agreements and the related purchase order together meet the contract existence criteria under ASXC 606-10-25-1.

Performance obligations

For the products sold by each of Napo and Jaguar, the single performance obligation identified above is Company’s promise to transfer the Company’s product Mytesi to Distributors based on specified payment and shipping terms in the arrangement.

Transaction price

For both Jaugar and Napo, the transaction price is the amount of consideration to which the Company expects to collect in exchange for transferring promised goods or services to a customer. The transaction price of Mytesi and Neonorm is the Wholesaler Aquistion Cost (“WAC”), net of variable considerations and price adjustments.

Allocate transaction price

For both Napo and Jaguar, the entire transaction price is allocated to the single performance obligaton contained in each contract.

Point in time recognition

For both Napo and Jaguar, a single performance obligation is satisfied at a point in time, upon the FOB terms of each contract when control, including title and all risks, has transferred to the customer.

Disaggregation of Product Revenue

Human

Sales of Mytesi are recognized as revenue when the products are delivered to the wholesalers. Revenues from the sale of Mytesi were $583,269 and $0 in the three months ended March 2018 and 2017, respectively. The Company recorded a reserve for estimated product returns under terms of agreements with wholesalers based on its historical returns experience. Reserves for returns at March 31, 2018 and December 31, 2017 were immaterial. If actual returns differed from our historical experience, changes to the reserved could be required in future periods.

Animal

The Company recognized Neonorm revenues of $43,698 and $44,544 for the three months ended March 31, 2018 and 2017, respectively, and Botanical Extract revenues of $0 and $30,000 in the three months ended March 31, 2018 and 2017, respectively. Revenues are recognized when title has transferred to the buyer. Sales of Neonorm Calf and Foal to distributors are made under agreements that may provide distributor price adjustments and rights of return under certain circumstances. Reserves for returns are analyzed periodically and are estimated based on historical return data. Reserves for returns and price adjustments at March 31, 2018 and December 31, 2017 were immaterial. Sales of Botanical Extract are recognized as revenue when the product is delivered to the customer which do not provide for return rights.

Collaboration Revenue

On January 27, 2017, the Company entered into a licensing, development, co-promotion and commercialization agreement with Elanco US Inc. (“Elanco”) to license, develop and commercialize Canalevia, the Company’s drug product candidate under investigation for treatment of acute and chemotherapy-induced diarrhea in dogs, and other drug product formulations of crofelemer for treatment of gastrointestinal diseases, conditions and symptoms in cats and other companion animals. Under the terms of the agreement, the Company received an initial upfront payment of $2,548,689, inclusive of reimbursement of past product and development expenses of $1,048,689, which was recognized as revenue ratably over the estimated development period of one year resulting in $177,389 and $459,700 in collaboration revenue in the three months ended March 31, 2018 and 2017, respectively. In addition to the upfront payments, Elanco reimbursed the Company for $0 and $288,166 in the three months ended March 31, 2018 and 2017 for certain development and regulatory expenses related to the planned target animal safety study and the completion of the Canalevia field study for acute diarrhea in dogs which were also included in collaboration revenue.

On November 1, 2017, the Company received a letter from Elanco serving as formal notice of their decision to terminate the agreement by giving the Company 90 days written notice. According to the agreement, termination became effective on January 30, 2018, which is 90 days after the date of the Notice. On the effective date of termination of the Elanco Agreement, all licenses granted to Elanco by the Company under the Elanco Agreement were revoked and the rights granted thereunder reverted back to the Company. Provisions in the agreement providing for the receipt of additional payments upon achievement of certain development, regulatory and sales milestones in an aggregate amount of up to $61.0 million payable throughout the term of the Elanco Agreement, as well as product development expense reimbursement for any additional product development expenses incurred, and royalty payments on global sales terminated on termination of the agreement.

Stock-Based Compensation

The Company’s 2013 Equity Incentive Plan and 2014 Stock Incentive Plan (see Note 10) provides for the grant of stock options, restricted stock and restricted stock unit awards.

The Company measures stock awards granted to employees and directors at fair value on the date of grant and recognizes the corresponding compensation expense of the awards, net of estimated forfeitures, over the requisite service periods, which correspond to the vesting periods of the awards. The Company issues stock awards with only service-based vesting conditions, and records compensation expense for these awards using the straight-line method.

The Company uses the grant date fair market value of its common stock to value both employee and non-employee options when granted. The Company revalues non-employee options each reporting period using the fair market value of the Company’s common stock as of the last day of each reporting period.

Classification of Securities

The Company applies the principles of ASC 480-10 “Distinguishing Liabilities from Equity” and ASC 815-40 “Derivatives and Hedging—Contracts in Entity’s Own Equity” to determine whether financial instruments such as warrants should be classified as liabilities or equity and whether beneficial conversion features exist. Financial instruments such as warrants that are evaluated to be classified as liabilities are fair valued upon issuance and are remeasured at fair value at subsequent reporting periods with the resulting change in fair value recorded in other income/(expense). The fair value of warrants is estimated using the Black-Scholes-Merton model and requires the input of subjective assumptions including expected stock price volatility and expected life.

Income Taxes

The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the financial statements or in the Company’s tax returns. Deferred taxes are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect in the years in which the differences are expected to reverse. Changes in deferred tax assets and liabilities are recorded in the provision for income taxes. The Company assesses the likelihood that its deferred tax assets will be recovered from future taxable income and, to the extent it believes, based upon the weight of available evidence, that it is more likely than not that all or a portion of deferred tax assets will not be realized, a valuation allowance is established through a charge to income tax expense. Potential for recovery of deferred tax assets is evaluated by estimating the future taxable profits expected and considering prudent and feasible tax planning strategies.

The Company accounts for uncertainty in income taxes recognized in the financial statements by applying a two-step process to determine the amount of tax benefit to be recognized. First, the tax position must be evaluated to determine the likelihood that it will be sustained upon external examination by the taxing authorities. If the tax position is deemed more-likely-than-not to be sustained, the tax position is then assessed to determine the amount of benefit to recognize in the financial statements. The amount of the benefit that may be recognized is the largest amount that has a greater than 50% likelihood of being realized upon ultimate settlement. The provision for income taxes includes the effects of any resulting tax reserves, or unrecognized tax benefits, that are considered appropriate, as well as the related net interest and penalties.

Comprehensive Loss

Comprehensive loss is defined as changes in stockholders’ equity (deficit) exclusive of transactions with owners (such as capital contributions and distributions). There was no difference between net loss and comprehensive loss for the three months ended March 31, 2018 and 2017.

Segment Data

Prior to the merger with Napo, the Company managed its operation as a single segment for the purposes of assessing performance and making operating decisions. The Company reorganized their segments to reflect the change in the organizational structure resulting from the merger with Napo. Post-merger with Napo, the Company manages its operations through two segments. The Company has two reportable segments—human health and animal health. The animal health segment is focused on developing and commercializing prescription and non-prescription products for companion and production animals. The human health segment is focused on developing and commercializing of human products and the ongoing commercialization of Mytesi™, which is approved by the U.S. FDA for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy.

The Company’s reportable segments net sales and net income consisted of:

	Three Months Ended March 31,
	2018			2017
Revenue from external customers
Human Health	$	583,269		$	—
Animal Health	43,698			822,410

Consolidated Totals	$	626,967		$	822,410

Interest expense
Human Health	$	105,891		$	—
Animal Health	496,131			180,072

Consolidated Totals	$	602,022		$	180,072

Depreciation and amortization
Human Health	$	314,530		$	—
Animal Health	15,031			15,031

Consolidated Totals	$	329,561		$	15,031

Segment profit
Human Health	$	(2,899,306	)	$	—
Animal Health	(2,797,331		)	(4,715,358		)

Consolidated Totals	$	(5,696,637	)	$	(4,715,358	)

The Company’s reportable segments assets consisted of the following:

	As of March 31,		As of December 31,
	2018		2017
Segment assets
Human Health	$	41,520,244	$	41,754,603
Animal Health	50,982,480		36,807,184

Total	$	92,502,724	$	78,561,787

The reconciliation of segments assets to the consolidated assets is as follows:

	As of March 31,			As of December 31,
	2018			2017
Total assets for reportable segments	$	92,502,724		$	78,561,787
Less: investment in subsidiary	(29,240,965		)	(29,240,965		)
Less: Intercompany loan	(2,000,000		)	(2,000,000		)
Less: intercompany receivable	(10,994,417		)	(3,691,616		)

Consolidated Totals	$	50,267,342		$	43,629,206

Basic and Diluted Net Loss Per Common Share

Basic net loss per common share is computed by dividing net loss attributable to common stockholders for the period by the weighted-average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing the net loss attributable to common stockholders for the period by the weighted-average number of common shares, including potential dilutive shares of common stock assuming the dilutive effect of potential dilutive securities. For periods in which the Company reports a net loss, diluted net loss per common share is the same as basic net loss per common share, because their impact would be anti-dilutive to the calculation of net loss per common share. Diluted net loss per common share is the same as basic net loss per common share for the three months ended March 31, 2018 and 2017.

Recent Accounting Pronouncements

In July 2017, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2017-11, “Earnings Per Share (Topic 260); Distinguishing Liabilities from Equity (Topic 480); Derivatives and Hedging (Topic 815): (Part I) Accounting for Certain Financial Instruments with Down Round Features, (Part II) Replacement of the Indefinite Deferral for Mandatorily Redeemable Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Non-controlling Interests with a Scope Exception” (“ASU 2017-11”), which addresses the complexity of accounting for certain financial instruments with down round features. Down round features are features of certain equity-linked instruments (or embedded features) that result in the strike price being reduced on the basis of the pricing of future equity offerings. Current accounting guidance creates cost and complexity for entities that issue financial instruments (such as warrants and convertible instruments) with down round features that require fair value measurement of the entire instrument or conversion option. The amendments in Part I of this ASU are effective for public business entities for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2018. The Company is currently evaluating the impact of the adoption of ASU 2017-11 on its consolidated financial statements.

In May 2017, the FASB issued ASU No. 2017-09, “Compensation—Stock Compensation (Topic 718): Scope of Modification Accounting” (“ASU 2017-09”), which provides guidance on determining which changes to the terms and conditions of share-based payment awards require an entity to apply modification accounting under Topic 718. The amendments in this ASU are effective for all entities for annual periods, and interim periods within those annual periods, beginning after December 15, 2017. Early adoption is permitted, including adoption in any interim period, for (1) public business entities for reporting periods for which financial statements have not yet been issued and (2) all other entities for reporting periods for which financial statements have not yet been made available for issuance. The amendments in this ASU should be applied prospectively to an award modified on or after the adoption date. The Company adopted this guidance on January 1, 2018 and such adoption did not have a material impact on the Company’s condensed consolidated financial statements.

In February 2017, the FASB issued ASU No. 2017-05, “Other Income—Gains and Losses from the Derecognition of Nonfinancial Assets (Subtopic 610-20): Clarifying the Scope of Asset Derecognition Guidance and Accounting for Partial Sales of Nonfinancial Assets” (“ASU 2017-05”), which clarifies the scope of the nonfinancial asset guidance in Subtopic 610-20. This ASU also clarifies that the derecognition of all businesses and nonprofit activities (except those related to conveyances of oil and gas mineral rights or contracts with customers) should be accounted for in accordance with the derecognition and deconsolidation guidance in Subtopic 810-10. The amendments in this ASU also provide guidance on the accounting for what often are referred to as partial sales of nonfinancial assets within the scope of Subtopic 610-20 and contributions of nonfinancial assets to a joint venture or other noncontrolled investee. The amendments in this ASU are effective for annual reporting reports beginning after December 15, 2017, including interim reporting periods within that reporting period. Public entities may apply the guidance earlier but only as of annual reporting periods beginning after December 15, 2016, including interim reporting periods within that reporting period. The Company adopted this guidance on January 1, 2018 and such adoption did not have a material impact on the Company’s condensed consolidated financial statements.

In January 2017, the FASB issued ASU No. 2017-04 related to goodwill impairment testing. This ASU eliminates Step 2 from the goodwill impairment test. Under the new guidance, if a reporting unit’s carrying amount exceeds its fair value, the entity will record an impairment charge based on that difference. The impairment charge will be limited to the amount of goodwill allocated to that reporting unit. Previously, if the fair value of a reporting unit was lower than its carrying amount (Step 1), an entity was required to calculate any impairment charge by comparing the implied fair value of goodwill with its carrying amount (Step 2). Additionally, under the new standard, entities that have reporting units with zero or negative carrying amounts will no longer be required to perform the qualitative assessment to determine whether to perform Step 2 of the goodwill impairment test. As a result, reporting units with zero or negative carrying amounts will generally be expected to pass the simplified impairment test; however, additional disclosure will be required of those entities. This ASU will be effective beginning in the first quarter of our fiscal year 2020. Early adoption is permitted for annual and interim goodwill impairment testing dates after January 1, 2017. The new guidance must be adopted on a prospective basis. The Company early adopted this ASU in 2017. For impact of the adoption of this standard, refer to Note 6 “Goodwill”.

In November 2016, the FASB issued Accounting Standards Update No. 2016-18, Statement of Cash Flows: Restricted Cash, or ASU 2016-18, that will require entities to show the changes in the total of cash, cash equivalents, restricted cash and restricted cash equivalents in the statement of cash flows. As a result, entities will no longer present transfers between cash and cash equivalents and restricted cash and restricted cash equivalents in the statement of cash flows. When cash, cash equivalents, restricted cash and restricted cash equivalents are presented in more than one line item on the balance sheet, the new guidance requires a reconciliation of the totals in the statement of cash flows to the related captions in the balance sheet. This reconciliation can be presented either on the face of the statement of cash flows or in the notes to the financial statements. Entities will also have to disclose the nature of their restricted cash and restricted cash equivalent balances. ASU 2016-18 becomes effective for fiscal years beginning after December 15, 2017, and interim periods within those years, with early adoption permitted. Any adjustments must be reflected as of the beginning of the fiscal year that includes that interim period. The Company adopted this guidance on January 1, 2018 and such adoption did not have a material impact on the Company’s condensed consolidated financial statements.

In October 2016, the FASB issued Accounting Standards Update 2016-16, Accounting for Income Taxes: Intra-Entitiy Asset Transfers of Assets Other than Inventory. Under current GAAP, the tax effects of intra-entity asset transfers (intercompany sales) are deferred until the transferred asset is sold to a third party or otherwise recovered through use. This is an exception to the principle in ASC 740, Income Taxes, that generally requires comprehensive recognition of current and deferred income taxes. The new guidance eliminates the exception for all intra-entity sales of assets other than inventory. As a result, a reporting entity would recognize the tax expense from the sale of the asset in the seller’s tax jurisdiction when the transfer occurs, even though the pre-tax effects of that transaction are eliminated in consolidation. Any deferred tax asset that arises in the buyer’s jurisdiction would also be recognized at the time of the transfer. The new guidance does not apply to intra-entity transfers of inventory. The ASU will be effective for public business entities in fiscal years beginning after December 15, 2017, including interim periods within those years. The Company adopted this guidance on January 1, 2018 and such adoption did not have a material impact on the Company’s condensed consolidated financial statements.

In August 2016, the FASB issued Accounting Standards Update, or ASU, No. 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments, which addresses the following cash flow issues: (1) debt prepayment or debt extinguishment costs; (2) settlement of zero-coupon debt instruments or other debt instruments with coupon interest rates that are insignificant in relation to the effective interest rate of the borrowing; (3) contingent consideration payments made after a business combination; (4) proceeds from the settlement of insurance claims; (5) proceeds from the settlement of corporate-owned life insurance policies, including bank-owned life insurance policies; (6) distributions received from equity method investees; (7) beneficial interests in securitization transactions; and (8) separately identifiable cash flows and application of the predominance principle. The amendments in this ASU are effective for public business entities for fiscal years beginning after December 15, 2017 and interim periods within those fiscal years and are effective for all other entities for fiscal years beginning after December 15, 2018 and interim periods within fiscal years beginning after December 15, 2019. Early adoption is permitted, including adoption in an interim period. The Company adopted this guidance on January 1, 2018 and such adoption did not have a material impact on the Company’s condensed consolidated financial statements.

In March 2016 the FASB issued ASU No. 2016-07, Investments—Equity Method and Joint Ventures (Topic 323): Simplifying the Transition to the Equity Method of Accounting. This new standard eliminates the requirement that when an investment qualifies for use of the equity method as a result of an increase in the level of ownership interest or degree of influence, an adjustment must be made to the investment, results of operations and retained earnings retroactively on a step-by-step basis as if the equity method had been in effect during all previous periods that the investment has been held. ASU 2016-07 is effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2017. The Company adopted this guidance on January 1, 2018 and such adoption did not have a material impact on the Company’s condensed consolidated financial statements.

In February 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-02, Leases (Topic 842), which provides guidance for accounting for leases. Under ASU 2016-02, the Company will be required to recognize the assets and liabilities for the rights and obligations created by leased assets. ASU 2016-02 is effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2018. The Company is currently evaluating the impact of the adoption of ASU 2016-02 on our consolidated financial statements.

In May 2014, the FASB issued ASU No. 2014-09, “Revenue from Contracts with Customers (Topic 606)” (ASU 2014-09), and subsequently issued modifications or clarifications in ASU No. 2015-14, “Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date,” ASU 2016-08, “Revenue from Contracts with Customers (Topic 606): Principal versus Agent Considerations (Reporting Revenue Gross versus Net),” ASU No. 2016-10, “Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing,” and ASU No. 2016-12, “Revenue from Contracts with Customers (Topic 606): Narrow-Scope Improvements and Practical Expedients.” The revenue recognition principle in ASU 2014-09 and the related guidance is that an entity should recognize revenue to depict the transfer of goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. ASU 2014-09 prescribes a five-step process for evaluating contracts and determining revenue recognition. In addition, new and enhanced disclosures are required. Companies may adopt the new standard either using the full retrospective approach, a modified retrospective approach with practical expedients, or a cumulative effect upon adoption approach. The Company has completed the process of evaluating the effects of the adoption of Topic 606 and determined that the timing and measurement of our revenues under the new standard is similar to that recognized under the previous revenue guidance. Similar to the current guidance, the Company will need to make significant estimates related to variable consideration at the point of sale, including chargebacks, rebates and product returns. Revenue will be recognized at a point in time upon the transfer of control of the Company’s products, which occurs upon delivery for substantially all of the Company’s sales. The Company adopted the new revenue guidance effective January 1, 2018, by recognizing the cumulative effect of initially applying the new standard as an increase to the opening balance of retained earnings as prescribed by the modified retrospective method of adoption. The adoption of ASU 2014-09, ASU 2016-10 and ASU 2016-12 did not have a material impact on Company’s condensed consolidated financial statements.

Business Combination

3 Months Ended

Mar. 31, 2018

Business Combination

Business Combination

3. Business Combination

As discussed in Note 1—Organization and Business, the Company completed a merger with Napo on July 31, 2017. Napo now operates as a wholly-owned subsidiary of Jaguar focused on human health and the ongoing commercialization of Mytesi, a Napo drug product approved by the U.S. FDA for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy.

The merger was accounted for under the acquisition method of accounting for business combinations and Jaguar was considered to be the acquiring company. Under the acquisition method of accounting, total consideration exchanged was:

	(Unaudited)
Fair value of Jaguar common stock	$	25,303,859
Fair value of Jaguar common stock warrants	630,859
Fair value of replacement restricted stock units	3,300,555
Fair value of replacement stock options	5,691
Cash	2,000,000
Effective settlement of receivable from Napo	464,295

Total consideration exchanged	$	31,705,259

The purchase price allocation to assets and liabilities assumed in the transaction was:

Current assets	$	2,578,114
Non-current assets	396,247
Identifiable intangible assets	36,400,000
Current liabilities	(4,052,180		)
Convertible notes payable	(12,473,501		)
Deferred tax liability	(13,181,242		)

Net assets acquired	9,667,438
Goodwill on acquisition	22,037,821

Total consideration	$	31,705,259

Under the acquisition method of accounting, certain identifiable assets and liabilities of Napo including identifiable intangible assets, inventory, debt and deferred revenue were recorded based on their estimated fair values as of the effective time of the Napo Merger. Tangible and other assets and liabilities were valued at their respective carrying amounts, which management believes approximate their fair values.

The Developed Technology (DT) is for the development and commercial processing of Mytesi™ (crofelemer 125mg delayed-release tablets), which is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy. The DT is a definite lived asset and is being amortized over a 15-year estimated useful life.

The acquired trademarks include Mytesi product trademark, domain names, and other brand related intellectual property. Trademark is a definite lived asset and is being amortized over a 15-year estimated useful life.

The acquired IPR&D projects relate to developing the proprietary technology into a commercially viable product for the several follow-on indications related to formulations of crofelemer. Crofelemer is in development for rare disease indications for infants and children with congenital diarrheal disorders (CDD) and short bowel syndrome (SBS), and for irritable bowel syndrome (IBS). These indications have completed some studies of clinical testing for safety and/or proof of concept efficacy at the time of the merger and the projects were determined to have substance. IPR&D is not amortized during the development period and is tested for impairment at least annually, or more frequently if indicators of impairment are identified. The Company terminated development of the indication for C. difficile infection (CDI) in Q4 2017. This indication was included as part of IPR&D at the time of the merger, and an impairment loss of $2,300,000 was recorded as a result of the decision to abandon the project in favor of the prioritization of the following: Mytesi is in development for follow-on indications in cancer therapy-related diarrhea (CTD), an important supportive care indication for patients undergoing primary or adjuvant therapy for cancer treatment; as supportive care for post-surgical inflammatory bowel disease patients (IBD); and as a second-generation anti-secretory agent for use in cholera patients. These indications did not have substance at the time of the merger and were not recognized as an asset apart from Goodwill.

The fair value of IPR&D, trademark, and DT was determined using the income approach, which was based on forecasts prepared by management.

The Napo Merger resulted in $22,037,821 of goodwill relating principally to synergies expected to be achieved from the combined operations and planned growth in new markets. Goodwill has been allocated to the human health segment.

As none of the goodwill, IPR&D, and developed technology acquired are expected to be deductible for income tax purposes, it was determined that a deferred income tax liability of $14,498,120 was required to reflect the book to tax differences of the merger. A deferred tax asset of $1,316,878 was accounted as an element of consideration for the replacement share-based payment awards as the replacement awards are expected to result in a future tax deduction.

The Company valued finished goods using a net realizable value approach, which resulted in a step-up of $84,806. Raw material was valued using the replacement cost approach.

The Company valued convertible debt assumed in the Napo Merger based on the value of the debt and the conversion option at $12,473,501 (see note 8). The Company incurred total acquisition related costs of $3,554,250. The acquisition related costs includes the fair value of $151,351 for 270,270 shares of Company’s common stock issued to a former creditor of Napo towards reimbursement of acquisition related costs. Acquisition related costs were expensed as incurred to general and administrative expenses in the condensed consolidated statements of operations and comprehensive loss.

The following table provides unaudited proforma results, prepared in accordance with ASC 805, for the three months ended March 31, 2018 and 2017, as if Napo was acquired on January 1, 2016.

	For the Three Months Ended March 31,
	2018		2017
Net sales	804,356		1,340,544
Net loss	(5,696,637	)	(7,647,024	)
Net loss per share, basic and diluted	(0.04	)	(0.54	)

The unaudited proforma results include adjustments to eliminate the interest on Napo’s historical convertible debt not assumed by Jaguar and debt exchanged for Jaguar common stock, record interest on convertible debt assumed by Jaguar, eliminate Napo impairment of investment in related party, and eliminate Napo’s loss from investment in related party. The Company made proforma adjustments to exclude the acquisition related costs for the three months ended March 31, 2017 because such costs are nonrecurring and are directly related to the Napo Merger.

The unaudited pro forma condensed results do not give effect to the potential impact of current financial conditions, regulatory matters, operating efficiencies or other savings or expenses that may be associated with the Napo Merger.The Company made proforma adjustments to exclude the acquisition related costs for the three months ended March 31, 2017. Unaudited pro forma amounts are not necessarily indicative of results had the Napo Merger occurred on January 1, 2016 or of future results.

The entire disclosure for a business combination (or series of individually immaterial business combinations) completed during the period, including background, timing, and recognized assets and liabilities. The disclosure may include leverage buyout transactions (as applicable).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=65885119&loc=d3e1497-128463

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=65885119&loc=d3e1490-128463

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=65885119&loc=d3e1392-128463

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e7008-128479

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=65885119&loc=d3e1486-128463

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e6927-128479

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 20
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+ Details

Fair Value Measurements

3 Months Ended

Mar. 31, 2018

Fair Value Measurements

Fair Value Measurements

4. Fair Value Measurements

ASC 820 “Fair Value Measurements,” defines fair value, establishes a framework for measuring fair value under generally accepted accounting principles and enhances disclosures about fair value measurements. Fair value is defined under ASC 820 as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value under ASC 820 must maximize the use of observable inputs and minimize the use of unobservable inputs. The standard describes a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value which are the following:

Level 1—Quoted prices in active markets for identical assets or liabilities;

Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data; and

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques.

The following table presents information about the Company’s derivative, conversion option and warrant liabilities that were measured at fair value on a recurring basis as of March 31, 2018 and December 31, 2017 and indicates the fair value hierarchy of the valuation:

	March 31, 2018
	Level 1		Level 2		Level 3		Total
Warrant liability	$	—	$	—	$	192,960	$	192,960
Derivative liability	—		—		15,000		15,000
Conversion option liability	—		—		—		—

Total fair value	$	—	$	—	$	207,960	$	207,960

	December 31, 2017
	Level 1		Level 2		Level 3		Total
Warrant liability	$	—	$	—	$	103,860	$	103,860
Derivative liability	—		—		11,000		11,000
Conversion option liability	—		—		111,841		111,841

Total fair value	$	—	$	—	$	226,701	$	226,701

The change in the estimated fair value of level 3 liabilities is summarized below:

	For The Three Months Ended
	March 31, 2018							March 31, 2017
	Warrant		Derivative		Conversion Option			Warrant
	liability		Liability		Liability			liability
Beginning fair value of level 3 liability	$	103,860	$	11,000	$	111,841		$	799,201
Extinguishment	—		—		(286,595		)	—
Change in fair value of level 3 liability	89,100		4,000		174,754			453,419

Ending fair value of level 3 liability	$	192,960	$	15,000	$	—		$	1,252,620

Warrant Liability

The warrants associated with the level 3 liability were issued in 2016 and were originally valued on November 29, 2016 using the Black-Scholes-Merton model with the following assumptions: stock price of $0.69, exercise price of $0.75, term of 5.5 years expiring May 2022, volatility of 71.92%, dividend yield of 0%, and risk-free interest rate of 1.87%. The $103,860 valuation at December 31, 2017 was computed using the Black-Scholes-Merton pricing model using a stock price of $0.1398, the strike price was $0.75 per share, the expected life was 4.41 years, the volatility was 96.36% and the risk free rate was 2.14%. The $192,960 valuation at March 31, 2018 was computed using the Black-Scholes-Merton pricing model using a stock price of $0.195, the strike price was $0.75 per share, the expected life was 4.16 years, the volatility was 109.62% and the risk free rate was 2.49%. The resulting $89,100 loss is included in change in fair value of warrants in the statement of income and comprehensive loss.

Derivative Liability

The derivative liability associated with the level 3 liability were associated with the June 2017 issuance of a convertible note payable. The Company computed fair values at the date of issuance of $15,000 and $5,000 for the repayment and the interest rate increase feature, respectively, using the Binomial Lattice Model, which was based on the generalized binomial option pricing formula. The $20,000 combined fair value was carved out and is included as a derivative liability on the Balance Sheet. The derviatives were revalued at December 31, 2017 using the same Model resulting in a combined fair value of $11,000. The resulting $9,000 gain is included in other income and expense in the Company’s statement of income and comprehensive loss. The derviatives were revalued again at March 31, 2018 using the same Model resulting in a combined fair value of $15,000. The resulting $4,000 loss is included in other income and expense in the Company’s statement of income and comprehensive loss.

Conversion Option Liability

In March 2017, Napo entered into an exchangeable note purchase agreement with two lenders for the funding of face amount of $1,312,500 in two $525,000 tranches of face amount $656,250. The Company assumed the notes at fair value of $1,312,500 as part of the Napo Merger. In December 2017, Napo amended the exchangeable note purchase agreement to extend the maturity of the first tranche and second tranche of notes to February 15, 2018 and April 1, 2018, respectively, increase the principal amount by 12%, and reduce the conversion price from $0.56 per share to $0.20 per share. The Company also issued 2,492,084 shares of common stock to the lenders in connection with this amendment to partially redeem $299,050 from the first tranche of the notes. The optional conversion option in the notes was bifurcated and accounted as a derivative liability at its fair value of $111,841 using the Black-Scholes-Merton model and the following criteria: stock price of $0.14 per share, conversion prices of $0.20 per share, expected life of 0.13 to 0.25 years, volatility of 86.29% to 160.78%, risk free rate of 1.28% to 1.39% and dividend rate of 0%. The $111,841 was included in conversion option liability on the balance sheet and in loss on extinguishment of debt on the statement of operations and comprehensive loss. The fair value of the conversion option liability was again revalued at March 23, 2018 using the Black-Scholes-Merton model using the following criteria: stock price of $0.21 per share, expected life of 0.11 years, volatility of 288.16%, risk free rate of 1.69% and dividend rate of 0%, resulting in an increase of $174,754 to the fair value of the conversion option liability and included in the change in fair value of warrants and conversion option liability in the statements of operations and comprehensive loss. The underlying debt was paid off in March of 2018 and the $286,595 conversion option liability was written off to other income in the statement of operations and comprehensive loss.

Related Party Transactions

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Related Party Transactions

3 Months Ended

Mar. 31, 2018

Related Party Transactions

5. Related Party Transactions

Due from former parent

The Company was a majority-owned subsidiary of Napo until May 18, 2015, the date of the Company’s IPO. Additionally, Lisa A. Conte, Chief Executive Officer of the Company, was also the Interim Chief Executive Officer of Napo Pharmaceuticals, Inc. The Company completed a merger with Napo on July 31, 2017, from which date Napo operates as a wholly-owned subsidiary of the Company—see Note 3—Business Combination.

The Company has total outstanding receivables (payables) from Napo at March 31, 2017 as follows:

	March 31,
	2017
Due from former parent	$	221,429
Royalty payable to former parent	(7		)

Net receivable (payable) to former parent	$	221,422

Due from former parent

Employee leasing and overhead allocation

Effective July 1, 2016, Napo agreed to reimburse the Company for the use of the Company’s employee’s time and related expenses, including rent and a fixed overhead amount to cover office supplies and copier use. The balance of unpaid employee leasing charges due from Napo was $277,529 at December 31, 2016. The total amount of such services was $407,267 and Napo remitted $465,625 for the three months ended March 31, 2017. The remaining unpaid balance of $219,171 is included in due from former parent in current assets on the Company’s balance sheet, and the receivable from Napo was effectively settled on merger and is included in the purchase consideration for the acquisition of Napo.

Loan to Napo

The Company loaned $2.0 million from proceeds of shares issued to an investor in connection with the merger to Napo, to partially extinguish Napo’s debt. The Company accounted for this amount as purchase consideration for the acquisition of Napo.

Other transactions

The Company periodically makes purchases on behalf of Napo, primarily including travel expenses and investor relations expenses. The balance of unpaid non-employee leasing charges due from Napo was $22,290 at December 31, 2016. The total amount of such purchases was $5,376 and Napo remitted $25,408 in the three months ended March 31, 2017. The remaining unpaid balance of $2,258 is included in due from former parent in current assets on the Company’s balance sheet, and the receivable from Napo was effectively settled on merger and is included in the purchase consideration for the acquisition of Napo.

Royalty payable to former parent and license fee payable to former parent and related agreement

On July 11, 2013, Jaguar entered into an option to license Napo’s intellectual property and technology (the “Option Agreement”). Under the Option Agreement, upon the payment of $100,000 in July 2013, the Company obtained an option for a period of two years to execute an exclusive worldwide license to Napo’s intellectual property and technology to use for the Company’s animal health business. The option price was creditable against future license fees to be paid to Napo under the License Agreement (as defined below).

In January 2014, the Company exercised its option and entered into a license agreement (the “License Agreement”) with Napo for an exclusive worldwide license to Napo’s intellectual property and technology to permit the Company to develop, formulate, manufacture, market, use, offer for sale, sell, import, export, commercialize and distribute products for veterinary treatment uses and indications for all species of animals. The Company was originally obligated to pay a one-time non-refundable license fee of $2,000,000, less the option fee of $100,000. At the Company’s option, the license fee could have been paid in common stock. In January 2015, the License Agreement was amended to decrease the one-time non-refundable license fee payable from $2,000,000 to $1,750,000 in exchange for acceleration of the payment of the fee. Given that Napo was a significant shareholder of the Company, the abatement of the license fee amount was recorded as a capital contribution in the accompanying condensed financial statements. The Company paid the final $425,000 in the three months ended March 31, 2016.

Milestone payments aggregating $3,150,000 were also potentially due to Napo based on regulatory approvals of various veterinary products. In addition to the milestone payments, the Company would owe Napo an 8% royalty on annual net sales of products derived from the Croton lechleri tree, up to $30,000,000 and then, a royalty of 10% on annual net sales of $30,000,000 or more. Additionally, if any other products are developed, the Company would owe Napo a 2% royalty on annual net sales of pharmaceutical prescription products that are not derived from Croton lechleri and a 1% royalty on annual net sales of non-prescription products that are not derived from Croton lechleri. The royalty term expires at the longer of 10 years from the first sale of each individual product or when there is no longer a valid patent claim covering any of the products and a competitive product has entered the market. However, because an IPO of at least $10,000,000 was consummated prior to December 31, 2015, the royalty was reduced to 2% of annual net sales of its prescription products derived from Croton lechleri and 1% of net sales of its non-prescription products derived from Croton lechleri and no milestone payment will be due and no royalties will be owed on any additional products developed.

The Company had unpaid royalties of $171 at December 31, 2016, which are netted with other receivables due from former parent in current assets in the Company’s balance sheet. The Company incurred $284 in royalties in the three months ended March 31, 2017, which are included in sales and marketing expense in the Company’s statement of operations and comprehensive loss, and paid $447 to Napo in the three months ended March 31, 2017. The remaining balance of unpaid royalties of $7 are netted with other receivables due from the former parent and are included in current assets in the Company’s balance sheet. The Company may, at its sole discretion, elect to remit any milestone payments and/or royalties in the form of the Company’s common stock.

In March 2018, the Company entered into a stock purchase agreement with Sagard Capital Partners, L.P. pursuant to which the Company, in a private placement, agreed to issue and sell to Sagard 5,524,926 shares of the Company’s series A convertible participating preferred stock, $0.0001 par value per share, for an aggregate purchase price of $9,199,001. As part of the agreement, Sagard will provide consulting and management advisory services in exchange for $450,000 in annual consulting fees, not to exceed $1,350,000 in aggregate payments.

Balance Sheet Components

3 Months Ended

Mar. 31, 2018

Balance Sheet Components

Balance Sheet Components

6. Balance Sheet Components

Land, Property and Equipment

Land, property and equipment at March 31, 2018 and December 31, 2017 consisted of the following:

	March 31,			December 31,
	2018			2017
Land	$	396,247		$	396,247
Lab equipment	811,087			811,087
Clinical equipment	64,870			64,870
Software	62,637			62,637
Furniture and fixtures	6,527			—

Total property and equipment at cost	1,341,368			1,334,841
Accumulated depreciation	(127,804		)	(112,773		)

Property and equipment, net	$	1,213,564		$	1,222,068

Depreciation and amortization expense was $15,031 in the three months ended March 31, 2018 and 2017 and was included in the statements of operations and comprehensive loss as follows:

	Three Months Ended
	March 31,
	2018		2017
Depreciation - lab equipment - research and development expense	$	6,568	$	6,568
Depreciation - clinical equipment - research and development expense	3,243		3,243
Depreciation - software - general and administrative expense	5,220		5,220

Total depreciation expense	$	15,031	$	15,031

Goodwill

The change in the carrying amount of goodwill at March 31, 2018 and December 31, 2017 was as follows:

	March 31,		December 31,
	2018		2017
Beginning balance	$	5,210,821	$	—
Goodwill acquired in conjunction with the Napo merger	—		22,037,821
Impairment	—		(16,827,000		)

Ending balance	5,210,821		5,210,821

Intangible assets

Intangible assets at March 31, 2018 and December 31, 2017 consisted of the following:

	March 31,			December 31,
	2018			2017
Developed technology	$	25,000,000		$	25,000,000
Accumulated developed technology amortization	(1,111,112		)	(694,445		)

Developed technology, net	23,888,888			24,305,555

In process research and development	11,100,000			11,100,000
Impairment	(2,300,000		)	(2,300,000		)

	8,800,000			8,800,000

Trademarks	300,000			300,000
Accumulated trademark amortization	(13,333		)	(8,333		)

Trademarks, net	286,667			291,667

Total intangible assets, net	$	32,975,555		$	33,397,222

Amortization expense was $421,667 and $0 in the three months ended March 31, 2018 and 2017.

Accrued Expenses

Accrued expenses at March 31, 2018 and December 31, 2017 consist of the following:

	March 31,		December 31,
	2018		2017
Accrued compensation and related:
Accrued vacation	$	287,522	$	264,304
Accrued payroll	1,150		150
Accrued payroll tax	28,016		30,617

	316,688		295,071
Accrued interest	342,498		659,961
Accrued research and development costs	668,850		668,850
Accrued audit	6,250		40,000
Accrued other	329,948		535,667

Total	$	1,664,234	$	2,199,549

Commitments and Contingencies

3 Months Ended

Mar. 31, 2018

Commitments and Contingencies

Commitments and Contingencies

7. Commitments and Contingencies

Effective July 1, 2015, the Company leases its San Francisco, California headquarters under a non-cancelable sub-lease agreement that expires August 31, 2018. The Company provided cash deposits of $122,163, consisting of a security deposit of $29,539 and prepayment of the last three months of the lease of $92,623, which are included in prepaid expenses and other current assets on the Company’s balance sheet.

Future minimum lease payments under non-cancelable operating leases as of December 31, 2017 are as follows:

Years ending December 31,	Amount
2018	$	153,705

Total minimum lease payments	$	153,705

The Company recognizes rent expense on a straight-line basis over the non-cancelable lease period. Rent expense under the non-cancelable operating lease was $90,278 for the three months ended March 31, 2018 and 2017, respectively. Rent expense is included in general and administrative expense in the statements of operations and comprehensive loss.

Asset transfer and transition commitment

On September 25, 2017, Napo entered into the Termination, Asset Transfer and Transition Agreement dated September 22, 2017 with Glenmark Pharmaceuticals Ltd. (“Glenmark”). As a result of the agreement, Napo now controls commercial rights for Mytesi® for all indications, territories and patient populations globally, and also holds commercial rights to the existing regulatory approvals for crofelemer in Brazil, Ecuador, Zimbabwe and Botswana. In exchange, Napo agrees to pay Glenmark 25% of any payment it receives from a third party to whom Napo grants a license or sublicense or with whom Napo partners in respect of, or sells or otherwise transfers any of the transferred assets, subject to certain exclusions, until Glenmark has received a total of $7 million.

Revenue sharing commitment

On December 14, 2017, the Company announced its entry into a collaboration agreement with Seed Mena Businessmen Services LLC (“SEED”) for Equilevia™, the Company’s non-prescription, personalized, premium product for total gut health in equine athletes. According to the terms of the Agreement, the Company will pay SEED 15% of total revenue generated from any clients or partners introduced to the Company by SEED in the form of fees, commissions, payments or revenue received by the Company or its business associates or partners, and the agreed-upon revenue percentage increases to 20% after the first million dollars of revenue. In return, SEED will provide the Company access to its existing UAE network and contacts and assist the Company with any legal or financial requirements. The agreement became effective on December 13, 2017 and will continue indefinitely until terminated by either party pursuant to the terms of the Agreement. Upon termination for any reason, the Company remains obligated to make Revenue Sharing Payments to SEED until the end of 2018.

Purchase Commitment

As of March 31, 2018, the Company had issued non-cancelable purchase orders to a vendor for $1.3 million.

Debt Obligations

See Note 8—Debt and Warrants.

Legal Proceedings

On July 20, 2017, a putative class action complaint was filed in the United States District Court, Northern District of California, Civil Action No. 3:17-cv-04102, by Tony Plant (the “Plaintiff”) on behalf of shareholders of the Company who held shares on June 30, 2017 and were entitled to vote at the 2017 Special Shareholders Meeting, against the Company and certain individuals who were directors as of the date of the vote (collectively, the “Defendants”), in a matter captioned Tony Plant v. Jaguar Animal Health, Inc., et al., making claims arising under Section 14(a) and Section 20(a) of the Exchange Act and Rule 14a-9, 17 C.F.R. § 240.14a-9, promulgated thereunder by the SEC. The claims allege false and misleading information provided to investors in the Joint Proxy Statement/Prospectus on Form S-4 (File No. 333-217364) declared effective by the Commission on July 6, 2017 related to the solicitation of votes from shareholders to approve the merger and certain transactions related thereto. The Company accepted service of the complaint and summons on behalf of itself and the United States-based director Defendants on November 1, 2017. The Company has not accepted service on behalf of, and Plaintiff has not yet served, the non-U.S.-based director Defendants. On October 3, 2017, Plaintiff filed a motion seeking appointment as lead plaintiff and appointment of Monteverde & Associates PC as lead counsel. That motion has been granted. Plaintiff filed an amended complaint against the Company and the United States-based director Defendants on January 10, 2018. If the Plaintiff were able to prove its allegations in this matter and to establish the damages it asserts, then an adverse ruling could have a material impact on the Company. However, the Company disputes the claims asserted in this putative class action case and is vigorously contesting the matter. On March 12, 2018, the Defendants moved to dismiss the amended complaint for failure to state a claim upon which relief may be granted. The Company believes that it is not probable that an asset has been impaired or a liability has been incurred as of the date of the financial statements and the amount of any potential loss is not reasonably estimable. The court has ordered a briefing schedule on the motion to dismiss and has tentatively set a hearing date of June 14, 2018.

Other than as described above, there are currently no claims or actions pending against us, the ultimate disposition of which could have a material adverse effect on our results of operations, financial condition or cash flows.

Contingencies

From time to time, the Company may be involved in legal proceedings (other than those noted above) arising in the ordinary course of business. The Company believes there is no litigation pending that could have, individually or in the aggregate, a material adverse effect on the financial position, results of operations or cash flows.

Debt and Warrants

3 Months Ended

Mar. 31, 2018

Debt and Warrants

8. Debt and Warrants

Convertible Notes

Convertible notes at March 31, 2018 and December 31, 2017 consist of the following:

	March 31,			December 31,
	2018			2017
February 2015 convertible notes payable	150,000			150,000
June 2017 convertible note payable	683,585			1,613,089
Napo convertible notes	10,875,300			12,153,389

	$	11,708,885		$	13,916,478
Less: unamortized debt discount and debt issuance costs	(142,902		)	(261,826		)

Net convertible notes payable obligation	$	11,565,983		$	13,654,652


Convertible notes payable - non-current	10,875,300			10,982,437

Convertible notes payable - current	$	690,683		$	2,672,215

Interest expense on the convertible notes for the three months ended March 31, 2018 and 2017 follows:

	Three Months Ended
	March 31,
	2018		2017
February 2015 convertible note nominal interest	$	4,438	$	4,438
June 2017 convertible note nominal interest	18,864		—
June 2017 convertible note accretion of debt discount	118,923		—
Napo convertibles note nominal interest	87,828		—

Total interest expense on convertible debt	$	230,053	$	4,438

Interest expense is classified as such in the statements of operations and comprehensive income.

February 2015 Convertible Note

In February 2015, the Company issued convertible promissory notes to two accredited investors in the aggregate principal amount of $250,000. These notes were issued pursuant to the convertible note purchase agreement dated December 23, 2014. In connection with the issuance of the notes, the Company issued the lenders warrants to purchase 22,320 shares at $5.60 per share, which expire December 31, 2017. Principal and interest of $103,912 was paid in May 2015 for $100,000 of these notes. The Company analyzed the beneficial nature of the conversion terms and determined that a BCF existed because the effective conversion price was less than the fair value at the time of the issuance. The Company calculated the value of the BCF using the intrinsic method. A BCF for the full face value was recorded as a discount to the notes payable and to additional paid-in capital. The full amount of the BCF was amortized to interest expense by the end of June 2015.

The remaining outstanding note of $150,000 is payable to an investor at an effective simple interest rate of 12% per annum, and was due in full on July 31, 2016. On July 28, 2016, the Company entered into an amendment to delay the repayment of the principal and related interest under the terms of the remaining note from July 31, 2016 to October 31, 2016.

On November 8, 2016, the Company entered into an amendment to extend the maturity date of the remaining note from October 31, 2016 to January 1, 2017. In exchange for the extension of the maturity date, on November 8, 2016, the Company’s board of directors granted the lender a warrant to purchase 120,000 shares of the Company’s common stock for $0.01 per share. The warrant is exercisable at any time on or before July 28, 2022, the expiration date of the warrant. The amendment and related warrant issuance resulted in the Company treating the debt as having been extinguished and replaced with new debt for accounting purposes due to meeting the 10% cash flow test.

* Extinguishment of debt

On January 31, 2017, the Company entered into another amendment to extend the maturity date of the remaining note from January 1, 2017 to January 1, 2018. In exchange for the extension of the maturity date, on January 31, 2017, the Company’s board of directors granted the lender a warrant to purchase 370,916 shares of the Company’s common stock for $0.51 per share. The warrant is exercisable at any time on or before January 31, 2019, the expiration date of the warrant. The amendment and related warrant issuance resulted in the Company treating the debt as having been extinguished and replaced with new debt for accounting purposes due to meeting the 10% cash flow test. The Company calculated a loss on the extinguishment of debt of $207,713, or the equivalent to the fair value of the warrants granted, which is included in loss on extinguishment of debt in the statements of operations and comprehensive loss in the year ended December 31, 2017. In March of 2018, the debtor agreed to accept the Company’s common stock as payment for all outstanding principal and interest. And in April of 2018, the Company issued 2,034,082 shares of common stock to pay off the principal and interest balance.

The $150,000 note is included in convertible notes payable on the balance sheet. The Company has unpaid accrued interest of $56,367 and $38,367, which is included in accrued expenses on the balance sheet as of March 31, 2018 and 2017, respectively, and incurred interest expense of $4,438 in the three months ended March 31, 2018 and 2017 which are included in interest expense in the statement of operations and comprehensive loss.

June 2017 Convertible Note

On June 29, 2017, the Company issued a secured convertible promisorry note to a lendor in the aggregate principal amount of $2,155,000 less an original issue discount of $425,000 and less $30,000 to cover the lender’s legal fees for net cash proceeds of $1,700,000. Interest on the outstanding balance will be paid 8% per annum from the purchase price date until the balance is paid in full. All interest calculations are computed on the basis of a 360-day year comprised of twelve (12) thirty (30) day months compounded daily and payable in accordance with the terms of the Note. All principal and interest on the debt is due in full on August 2, 2018. The Company accrued interest of $4,548 and $6,180 at March 31, 2018 and December 31, 2017, which is included in accrued expenses on the balance sheet, and incurred nominal interest of $18,864 in interest expense in the three months ended March 31, 2018 which is included in interest expense in the statement of operations and comprehensive loss. The Company accreted debt discount of $118,923 for the three months ended March 31, 2018 which is included in interest expense in the statement of operations and comprehensive loss. The lender has the right to convert all or any portion of the outstanding balance into the Company’s common stock at $1.00 per share. The Note provides the lender with an optional monthly redemption that allows for the monthly payment of up to $350,000 at the creditor’s option.

The Note provides for two separate features that result in a derivative liability:

Repayment of mandatory default amount upon an event of default—upon the occurrence of any event of default, the lendor may accelerate the Note resulting in the outstanding balance becoming immediately due and payable in cash; and

Automatic increase in the interest rate on and during an event of default—during an event of default, the interest rate will increase to the lesser of 17% per annum or the maximum rate permitted under applicable law.

The Company computed fair values at June 30, 2017 of $15,000 and $5,000 for the repayment and the interest rate increase feature, respectively, using the Binomial Lattice Model, which was based on the generalized binomial option pricing formula. The $20,000 combined fair value was carved out and is included as a derivative liability on the Balance Sheet. The derviatives were revalued at December 31, 2017 and March 31, 2018 using the same Model resulting in a combined fair value of $11,000 and $15,000, respectively. The $4,000 loss is included in other income and expense in the statement of income and comprehensive income.

The balance of the note payable of $540,684, consisting of the $2,155,000 face value of the note less note discounts and debt issuance costs of $509,000, less the $20,000 derivative liability, less principal payments of $1,451,454, plus the accretion of the debt discount and debt issuance costs of $366,098, is included in convertible notes payable on the balance sheet.

Interest payable on the accumulation of all convertible notes was $121,018 and $118,228 at March 31, 2018 and December 31, 2017.

Convertible Notes Payable

In March 2017, Napo entered into an exchangeable Note Purchase Agreement with two lenders for the funding of face amount of $1,312,500 in two $525,000 tranches of face amount $656,250. The notes bear interest at 3% and mature on December 1, 2017. Interest may be paid at maturity in either cash or shares of Jaguar per terms of the exchangeable note purchase agreement. The notes may be exchanged for up to 2,343,752 shares of Jaguar common stock, prior to maturity date. The Company assumed the notes at fair value of $1,312,500 as part of the Napo Merger. At December 31, 2017, the accrued interest on these notes is $29,774. The fair value was calculated using the Binomial Lattice Model using the following criteria: stock price of $0.5893, expected term of tranche 1 of 0.34 years and tranche 2 of 0.42 years, conversion price of $0.56, volatility of tranche 1 of 70% and tranche 2 of 100%, and risk free rate of tranche 1 of 1.09% and tranche 2 of 1.13%.

First Amendment to Note Purchase Agreement and Notes

In December 2017, Napo amended the exchangeable note purchase agreement to extend the maturity of the first tranche and second tranche of notes to February 15, 2018 and April 1, 2018, respectively, increase the principal amount by 12%, and reduce the conversion price from $0.56 per share to $0.20 per share. The Company also issued 2,492,084 shares of common stock to the lenders in connection with this amendment to partially redeem $299,050 from the first tranche of the notes. The amended face value of the notes is $1,170,950. This amendment resulted in the Company treating the notes as having been extinguished and replaced with new notes for accounting purposes due to meeting the 10% cash flow test. The Company calculated a loss on extinguishment of notes of $157,500, which is included in loss on extinguishment of debt in the Company’s consolidated statement of operations and comprehensive income. The conversion option in the notes was bifurcated and accounted as a conversion option liability at its fair value of $111,841 using the Black-Scholes-Merton model and the following criteria: stock price of $0.14 per share, conversion prices of $0.20 per share, expected life of 0.13 to 0.25 years, volatility of 86.29% to 160.78%, risk free rate of 1.28% to 1.39% and dividend rate of 0%. The $111,841 was included in conversion option liability on the balance sheet and in loss on extinguishment of debt on the statement of operations and comprehensive loss.

At December 31, 2017, the balance of the notes payable of $1,170,950 was included in convertible notes payable in current liabilities on the consolidated balance sheet. The accrued interest on these notes of $29,774 is included in accrued expenses in current liabilities on the consolidated balance sheet.

Second Amendment to Note Purchase Agreement and Notes

On February 16, 2018, Napo amended the exchangeable note purchase agreement to extend the maturity date of the Second Tranche Notes from April 1, 2018 to May 1, 2018. In addition, the Company also issued 3,783,444 shares of Common Stock to the Purchasers as repayment of the remaining $435,950 aggregate principal amount of the original issue discount exchangeable promissory notes previously issued by Napo to the Purchasers on March 1, 2017 pursuant to the Note Purchase Agreement (the “First Tranche Notes”) and $18,063 in accrued and unpaid interest thereon. On March 23, 2018, the Company paid off the remaining $735,000 of principal and $20,699.38 in interest due on the second tranche debt in cash with proceeds from the March 23, 2018 equity financing. The fair value of the conversion option liability was again revalued at March 23, 2018 using the Black-Scholes-Merton model using the following criteria: stock price of $0.21 per share, expected life of 0.11 years, volatility of 288.16%, risk free rate of 1.69% and dividend rate of 0%, resulting in an increase of $174,754 to the fair value of the conversion option liability and included in the change in fair value of warrants and conversion option liability in the statements of operations and comprehensive loss. The underlying debt was paid off in March of 2018 and the $286,595 conversion option liability was written off to other income in the statement of operations and comprehensive loss.

Convertible Long-term Debt

In December 2016, Napo entered into a note purchase agreement which provided for the sale of up to $12,500,000 face amount of notes and issued convertible promissory notes (the Napo December 2016 Notes) in the aggregate face amount of $2,500,000 to three lenders and received proceeds of $2,000,000 which resulted in $500,000 of original issue discount. In July 2017, Napo issued convertible promissory notes (the Napo July 2017 Notes) in the aggregate face amount of $7,500,000 to four lenders and received proceeds of $6,000,000 which resulted in $1,500,000 of original issue discount. The Napo December 2016 Notes and the Napo July 2017 Notes mature on December 30, 2019 and bear interest at 10% with interest due each six-month period after December 30, 2016. On June 30, 2017, the accrued interest of $125,338 was added to principal of the Napo December Notes, and the new principal balance became $2,625,338. Interest may be paid in cash or in the stock of Jaguar per terms of the note purchase agreement. In each one year period beginning December 30, 2016, up to one-third of the principal and accrued interest on the notes may be converted into the common stock of the merged entity at a conversion price of $0.925 per share. The Company assumed these convertible notes at fair value of $11,161,000 as part of the Napo Merger. The fair value was calculated using the Binomial Lattice Model using the following criteria: stock price of $0.5893, expected term of 2.42 years, conversion price of $0.925, volatility of 115%, and risk free rate of 1.41%. The $1,035,661 difference between the fair value of the notes and the principal balance is being amortized over the twenty-nine (29) month period from July 31, 2017 to December 31, 2019 or $178,562 and is recorded as a contra interest expense in the statement of operations and comprehensive loss. Interest expense is paid every six months through the issuance of common stock. On March 16, 2018, $534,775 of interest accrued through January 31, 2018 and $169,950 of certain legal expenses were paid through the issuance of 4,285,423 shares of the Company’s common stock. At March 31, 2018 and December 31, 2017, the unamortized balance of the note payable is $10,875,300 and $10,982,438 which are included in Convertible Long-term Debt on the balance sheet, and the accrued interest on these notes is $163,670 and $448,779 as of March 31, 2018 and December 31, 2017, and are included in accrued interest on the balance sheets. Interest of $249,666 less $107,167 of debt appreciation amortization or $142,529 was included in interest expense in the statements of operations and comprehensive income in the three months ended March 31, 2018.

Long-term Debt

As of March 31, 2018 and December 31, 2017, the net Jaguar long-term debt obligation was as follows:

	March 31,		December 31,
	2018		2017
Debt and unpaid accrued end-of-term payment	$	—	$	1,636,639
Unamortized note discount	—		(6,615		)
Unamortized debt issuance costs	—		(20,780		)

Net debt obligation	$	—	$	1,609,244


Current portion of long-term debt	$	—	$	1,609,244
Long-term debt, net of discount	—		—

Total	$	—	$	1,609,244

Interest expense on the Jaguar long-term debt for the three months ended March 31, 2018 and 2017 was as follows:

	Three Months Ended
	March 31,
	2018		2017
Nominal interest	$	19,344	$	78,861
Accretion of debt discount	20,779		11,678
Accretion of end-of-term payment	52,561		48,655
Accretion of debt issuance costs	6,616		36,439

	$	99,300	$	175,633

Interest payable on the Jaguar long-term debt was $0 and $9,422 at March 31, 2018 and December 31, 2017, respectively.

In August 2015, the Company entered into a loan and security agreement with a lender for up to $8.0 million, which provided for an initial loan commitment of $6.0 million. The loan agreement requires the Company to maintain $4.5 million of the proceeds in cash, which may be reduced or eliminated on the achievement of certain milestones. An additional $2.0 million is available contingent on the achievement of certain further milestones. The agreement has a term of three years, with interest only payments through February 29, 2016. Thereafter, principal and interest payments will be made with an interest rate of 9.9%. Additionally, there will be a balloon payment of $600,000 on August 1, 2018 (as modified in the third amendment to the Loan Agreement). This amount is being recognized over the term of the loan agreement and the effective interest rate, considering the balloon payment, is 15.0%. Proceeds to the Company were net of a $134,433 debt discount under the terms of the loan agreement. This debt discount is being recorded as interest expense, using the interest method, over the term of the loan agreement. Under the agreement, the Company is entitled to prepay principal and accrued interest upon five days prior notice to the lender. In the event of prepayment, the Company is obligated to pay a prepayment charge. If such prepayment is made during any of the first twelve months of the loan agreement, the prepayment charge will be (a) during such time as the Company is required to maintain a minimum cash balance, 2% of the minimum cash balance amount plus 3% of the difference between the amount being prepaid and the minimum cash balance, and (b) after such time as the Company is no longer required to maintain a minimum cash balance, 3% of the amount being prepaid. If such prepayment is made during any time after the first twelve months of the loan agreement, 1% of the amount being prepaid.

On April 21, 2016, the loan and security was amended upon which the Company repaid $1.5 million of the debt out of restricted cash. The amendment modified the repayment amortization schedule providing a four-month period of interest only payments for the period from May through August 2016.

On July 7, 2017, the Company entered into the third amendment to the Loan Agreement upon which the Company paid $1.0 million of the outstanding loan balance, and the Lender waived the Prepayment Charge associated with such prepayment. The Third Amendment modified the repayment schedule providing a three-month period of interest only payments for the period from August 2017 through October 2017, and reduced the required cash amount that the Company must keep on hand to $500,000, which will be reduced following the Lender’s receipt of each principal repayment subsequent to the $1.0 million. As the present value of the cash flows under the terms of the third amendment is less than 10% different from the remaining cash flows under the terms of the loan agreement prior to the amendment, the third amendment was accounted as a debt modification.

On March 23, 2018, the Company paid off the remaining $689,345 of principal, $4,471 of interest, and the end-of-term payment of $600,000 in cash with proceeds from the March 23, 2018 equity financing.

Notes Payable

As of March 31, 2018 and December 31, 2017, the net Jaguar short-term notes payable was as follows:

	Notes Payable
	March 31,			December 31,
	2018			2017
December 2017 note payable	$	1,587,500		$	1,587,500
February 2018 note payable	2,240,909			—
March 2018 note payable	1,090,341			—

	4,918,750			1,587,500
Less: unamortized net discount and debt issuance costs	(1,262,651		)	(446,347		)

Net convertible notes payable obligation	$	3,656,099		$	1,141,153

Interest expense on the Jaguar short-term notes payable for the three months ended March 31, 2018 and 2017 was as follows:

	Three Months Ended
	March 31,
	2018		2017
Nominal interest	$	49,659	$	—
Accretion of debt discount	204,946		—

Total interest expense on notes payable	$	254,605	$	—

Interest payable on the Jaguar short-term notes payable was $57,793 and $8,134 at March 31, 2018 and December 31, 2017, respectively.

On December 8, 2017, the Company entered into a securities purchase agreement with CVP pursuant to which the Company issued a promissory note in the aggregate principal amount of $1,587,500 for an aggregate purchase price of $1,100,000. The Note carries an original issue discount of $462,500, and the initial principal balance also includes $25,000 to cover CVP’s transaction expenses. The Company will use the proceeds for general corporate purposes. The Note bears interest at the rate of 8% per annum and matures on September 8, 2018. The balance of the note payable of $1,301,783 consists of the $1,587,500 face value of the note less note discounts and debt issuance costs of $487,500, plus the accretion of the debt discount and debt issuance costs of $201,783, is included in notes payable in the current liabilities section of the balance sheet. The Company accrued interest of $40,364 and $8,333 at March 31, 2018 and December 31, 2017, which is included in accrued expenses on the balance sheet, and incurred nonmal interest of $32,230 in the three months ended March 31, 2018 which is included in interest expense in the statement of operations and comprehensive loss. The Company accreted debt discount of $160,630 in the three months ended March 31, 2018 which is included in interest expense in the statement of operations and comprehensive loss.

In addition, beginning on January 31, 2018, CVP will have the right to redeem a portion of the outstanding balance of the Note in any amount up to $350,000 per month for the first six months following the Purchase Price Date and $500,000 per month thereafter. For purposes of calculating the maximum amount that may be redeemed in any month, the amounts redeemed under the Note will be aggregated with all redemption amounts under the Secured Convertible Promissory Note in the original principal amount of $2,155,000 issued by the Company in favor of the creditor on June 29, 2017.

On February 26, 2018, the Company entered into a securities purchase agreement with Chicago Venture Partners, L.P. (“CVP”), pursuant to which the Company issued to CVP a promissory note in the aggregate principal amount of $2,240,909 for an aggregate purchase price of $1,560,000. The Note carries an original issue discount of $655,909, and the initial principal balance also includes $25,000 to cover CVP’s transaction expenses. The Company will use the proceeds for general corporate purposes and working capital. The Note bears interest at the rate of 8% per annum and matures on (i) August 26, 2019 if the Company has raised at least $12 million in equity after the issuance date of the Note (the “Redemption Start Condition”) and on or before April 1, 2018 or (ii) November 26, 2018 if the Redemption Start Condition is not satisfied on or before April 1, 2018. The balance of the note payable of $1,599,217 consisting of the $2,240,909 face value of the note less note discounts and debt issuance costs of $680,909, plus the accretion of the debt discount and debt issuance costs of $39,217, is included in notes payable in the current liabilities section of the balance sheet. The Company accrued interest of $15,489 at March 31, 2018, which is included in accrued expenses on the balance sheet, and incurred nonmal interest of $15,489 in the three months ended March 31, 2018 which is included in interest expense in the statement of operations and comprehensive loss. The Company accreted debt discount of $39,217 in interest expense for the three months ended March 31, 2018 which is included in interest expense in the statement of operations and comprehensive loss.

In addition, beginning on the Redemption Start Date (as defined below), the Company has the right to redeem all or any portion of the outstanding balance of the Note in cash or as otherwise mutually agreed upon between the parties. The Redemption Start Date is the date that is (i) seven months from the effective date of the Note (the “Effective Date”) if the Redemption Start Condition is satisfied by April 1, 2018 or (ii) six months from the Effective Date if (x) the Redemption Start Condition is not satisfied by April 1, 2018 or (y) at any time after the Effective Date CVP breaches any of the covenants set forth in the Securities Purchase Agreement.

If the Redemption Start Condition is satisfied by April 1, 2018, the Company and CVP also agree to amend that certain Secured Convertible Promissory Note in the original amount of $2,155,000 issued by Company in favor of CVP on June 29, 2017 (the “June 2017 Note”) and that certain Secured Promissory Note in the original amount of $1,587,500 issued by Company in favor of CVP on December 8, 2017 (the “December 2017 Note,” and together with the June 2017 Note, the “Prior Notes”) to (i) extend the maturity date of the Prior Notes to August 26, 2019, (ii) postpone the date on which CVP can exercise its right to redeem the Prior Notes to September 26, 2018 and (iii) limit the aggregate amount that CVP is permitted to redeem on a monthly basis to $500,000, which amount is the maximum aggregate redemption amount for the Prior Notes and the Note collectively.

The Securities Purchase Agreement and the other transaction documents and obligations of the Company thereunder are subject in all respects to the terms of that certain subordination agreement and right to purchase debt (the “Subordination Agreement”) that the Company entered into with CVP with Hercules Capital, Inc. (“Hercules”) on June 29, 2017, pursuant to which (i) CVP subordinated (a) all of the Company’s debt and obligations to CVP to all of the Company’s indebtedness and obligations to Hercules and (b) all of CVP’s security interest, if any, in the Company’s assets to all of Hercules’ security interest in the Company’s assets and (ii) Hercules granted CVP the right to purchase 100% of the debt under the Company’s term loan so long as the purchase includes the full pay-out of funds owed to Hercules under the term loan at such time.

The Company also entered into a security agreement with CVP, pursuant to which CVP will receive a security interest in substantially all of the Company’s assets. The security interest is effective upon CVP’s purchase of the Company’s outstanding obligations under that certain loan and security agreement, dated August 18, 2015, between the Company and Hercules Capital, Inc. or upon such time that the Hercules Loan is otherwise repaid in full.

On March 21, 2018, the Company entered into a securities purchase agreement with CVP, pursuant to which the Company issued to CVP a promissory note in the aggregate principal amount of $1,090,341 for an aggregate purchase price of $750,000. The Note carries an original issue discount of $315,341, and the initial principal balance also includes $25,000 to cover CVP’s transaction expenses. The Company will use the proceeds to fully repay certain prior secured and unsecured indebtedness. The Note bears interest at the rate of 8% per annum and matures on September 21, 2019.

Under the Securities Purchase Agreement, the Company is subject to certain covenants, including the obligations of the Company to: (i) timely file all reports required to be filed under Sections 13 or 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) and not terminate its status as an issuer required to file reports under the Exchange Act; (ii) maintain listing of the Company’s common stock on a securities exchange; (iii) avoid trading in the Company’s common stock from being suspended, halted, chilled, frozen or otherwise ceased; (iv) not issue any variable securities (i.e., Company securities that (a) have conversion rights of any kind in which the number of shares that may be issued pursuant to the conversion right varies with the market price of the Company’s common stock or (b) are or may become convertible into shares of the Company’s common stock with a conversion price that varies with the market price of such stock) that generate gross cash proceeds to the Company of less than the lesser of $1 million and the then-current outstanding balance of the Note without CVP’s prior consent; (v) not grant a security interest in its assets without CVP’s prior consent; (vi) not issue any shares of common stock to certain institutional investors; (vii) repay the Hercules Loan (as defined below) on or before March 26, 2018; (viii) repay all outstanding amounts owed to certain noteholders within five trading days of the date of issuance of the Note; (ix) not incur any debt other than in the ordinary course of business, and in no event greater than $10,000, without CVP’s prior consent; and (x) other customary covenants and obligations, for which the Company’s failure to comply may be subject to certain liquidated damages. The Hercules Loan was repaid in full on March 23, 2018, simultaneously with the closing of the Preferred Stock Offering.

In addition, beginning seven months from the effective date of the Note or at any time after the Effective Date if the Company breaches any of the covenants set forth in the Securities Purchase Agreement, CVP has the right to redeem all or any portion of the outstanding balance of the Note in cash or as otherwise mutually agreed upon between the parties.

Since the Redemption Start Condition (i.e., the Company raised at least $12 million in equity after the issuance date of the Note) was satisfied by April 1, 2018 as a result of the consummation of the Preferred Stock Offering and Common Stock Offering, the Company and CVP agreed to amend the Notes issued to CVP on June 29, 2017, December 8, 2017 and February 26, to limit the aggregate amount that CVP is permitted to redeem on a monthly basis to $500,000, which amount is the maximum aggregate redemption amount for the Notes collectively.

Warrants

On November 22, 2016, the Company entered into a Securities Purchase Agreement, or the 2016 Purchase Agreement, with certain institutional investors, pursuant to which the Company sold securities to such investors in a private placement transaction, which we refer to herein as the 2016 Private Placement. In the 2016 Private Placement, the Company sold an aggregate of 1,666,668 shares of the Company’s common stock at a price of $0.60 per share for gross proceeds of approximately $1.0 million. The investors in the 2016 Private Placement also received (i) warrants to purchase up to an aggregate of 1,666,668 shares of the Company’s common stock, at an exercise price of $0.75 per share, or the Series A Warrants, and the Placement Agent received warrants to purchase 133,333 shares of our common stock in lieu of cash for service fees with the same terms as the investors; (ii) warrants to purchase up to an aggregate 1,666,668 shares of the Company’s common stock, at an exercise price of $0.90 per share, or the Series B Warrants, and (iii) warrants to purchase up to an aggregate 1,666,668 shares of our common stock, at an exercise price of $1.00 per share, or the Series C Warrants and, together with the Series A Warrants and the Series B Warrants, the 2016 Warrants. The warrants were granted in three series with different terms. The warrants were valued using the Black-Scholes-Merton warrant pricing model as follows:

Series A Warrants and Placement Agent Warrants: 1,666,668 warrant shares with a strike price of $0.75 per share and an expiration date of May 29, 2022; and 133,333 warrant shares to the placement agent with a strike price of $0.75 and an expiration date of May 29, 2022; the expected life is 5.5 years, the volatility is 71.92% and the risk free rate is 1.87% in valuing these warrants.

Series B Warrants: 1,666,668 warrant shares with a strike price of $0.90 per share and an expiration date of November 29, 2017; the expected life is one year, the volatility is 116.65% and the risk free rate is 0.78% in valuing these warrants.

Series C Warrants: 1,666,668 warrant shares with a strike price of $1.00 per share and an expiration date of May 29, 2018; the expected life is 1.5 years, the volatility is 116.92% and the risk free rate is 0.94%.

The warrant valuation date was November 29, 2016 and the closing price of $0.69 per share was used in determining the fair value of the warrants. The series A warrants and placement agent warrants were valued at $756,001 and were classified as a warrant liability in the Company’s balance sheet. The series A warrants and placement agent warrants were revalued on December 31, 2016 at $799,201 which is included in the Company’s balance sheet, and the $43,200 increase is included in the Company’s statements of operations and comprehensive loss. The stock price was $0.716, the strike price was $0.75 per share, the expected life was 5.41 years, the volatility was 73.62% and the risk free rate was 2.0%. The series B and C warrants were classified as equity, and as such were not subject to revaluation at year end. Costs incurred in connection with the issuance were allocated based on the relative fair values of the Series A and the Series B and C warrants. The series A warrants and placement agent warrants were revalued on December 31, 2017 at $103,860 and is included in the Company’s balance sheet. The valuation reflects a reduction of $695,341 from the $799,201 December 31, 2016 valuation. The reduction is included in the Company’s statements of operations and comprehensive loss. The $103,860 valuation at December 31, 2017 was computed using the Black-Scholes-Merton pricing model using a stock price of $0.1398, the strike price was $0.75 per share, the expected life was 4.41 years, the volatility was 96.36% and the risk free rate was 2.14%.

On July 31, 2017, the Company entered into Warrant Exercise Agreements (the “Exercise Agreements”) with certain holders of Series C Warrants (the “Exercising Holders”), which Exercising Holders own, in the aggregate, Series C Warrants exercisable for 908,334 shares of the Company’s common stock. Pursuant to the Exercise Agreements, the Exercising Holders and the Company agreed that the Exercising Holders would exercise their Series C Warrants with respect to 908,334 shares of common stock underlying such Series C Warrants for a reduced exercise price equal to $0.40 per share. The Company received aggregate gross proceeds of approximately $363,334 from the exercise of the Series C Warrants by the Exercising Holders. The difference between the pre-modification and post-modification fair value of $23,000 was expensed in general and administrative expense in the statements of operations and comprehensive income. The pre-modification fair value was computed using the Black-Scholes-Merton model using a stock price of $0.56 (fair market value on modification date), original strike price of $1.00, expected life of 0.83 years, volatility of 115.28%, risk-free rate of 1.20% to arrive at a fair value of $0.1347 per share. The post-modification fair value was computed using the intrinsic value on the date of modification or $0.16 per share.

The Company granted warrants to purchase the 1,224,875 shares of common stock of the Company at an exercise price price of $0.08 per share to replace Napo warrants upon the consummation of the Merger. Of the 1,224,875 warrants, 145,457 warrants expire on December 31, 2018 and 1,079,418 warrants expire on December 31, 2025. The warrants were valued at $630,859, using the Black-Scholes-Merton warrant pricing model as follows: exercise price of $0.08 per share, stock price of $0.56 per share, expected life ranging from 1.42 years to 8.42 years, volatility ranging from 75.07% to 110.03%, and risk free rate ranging from 1.28% to 2.14%. The warrants were accounted in equity.

The Company’s warrant activity is summarized as follows:

	Three Months Ended	Year Ended
	March 31,	December 31,
	2018	2017
	(in shares)
Beginning balance	4,820,025	5,968,876
Warrants granted	—	1,595,791
Warrants exercised	—	(908,334	)
Warrants cancelled	—	(1,836,308	)

Ending balance	4,820,025	4,820,025

Stockholders' Equity

3 Months Ended

Mar. 31, 2018

Stockholders' Equity

Stockholders' Equity

9. Stockholders’ Equity

Common Stock

On July 31, 2017, the Company filed a third amended and restated certificate of incorporation authorizing the Company to issue 250,000,000 shares of common stock $0.0001 par value and 50,000,000 of convertible non-voting common stock, $0.0001 par value per share. The holders of common stock are entitled to one vote for each share of common stock held at all meetings of stockholders. The holders of non-voting common stock are not entitled to vote, except on an as converted basis with respect to any change of control of the Company that is submitted to the stockholders of the Company for approval.The number of authorized shares of common stock may be increased or decreased by the affirmative vote of the holders of shares of capital stock of the Company representing a majority of the votes represented by all shares (including Preferred Stock) entitled to vote. Shares of Jaguar non-voting common stock have the same rights to dividends and other distributions and are convertible into shares of Jaguar common stock on a one-for-one basis upon transfers to non-affiliates of Nantucket (“former creditor of Napo”), upon the release from escrow of certain non-voting shares held by the former creditors of Napo to the legacy stockholders of Napo under specified conditions and at any time on or after April 1, 2018 at the option of the respective holders thereof. And on March 12, 2018, the Company filed a fourth amended and restated certificate of incorporation authorizing the Company to issue 500,000,000 shares of common stock $0.0001 par value and 50,000,000 of convertible non-voting common stock, $0.0001 par value per share.

On June 28, 2017, the Company entered into a Common Stock Purchase Agreement with an existing private investor. Upon execution of the agreement the Company sold 100,000 shares of its common stock in exchange for $50,000 in cash proceeds.

On July 31, 2017, the Company entered into a Common Stock Purchase Agreement with an existing investor. Upon execution of the agreement the Company sold 3,243,243 shares of voting common stock in exchange for $3.0 million in cash proceeds.

On July 31, 2017, the Company completed the merger with Napo and changed it’s name to Jaguar Health, Inc. The Company issued 2,282,445 shares of voting common stock and 43,173,288 shares of non-voting stock at the time the merger was consummated.

In November 2017, the Company issued 235,134 shares of common stock to an existing investor in exchange for $43,829 in services rendered.

In November and December 2017, the Company issued 6,492,084 shares of common stock to a convertible debt holder as redemption of $900,362 of debt principal and interest.

In November and December 2017, in a private investment in public entitites, the Company issued 5,100,000 shares of its common stock with a single investor in exchange for $555,262 in cash. And in January, February and March 2018, the Company issued an additional 9,746,413 shares of its common stock to the investor for an additional $1,305,774.

In December 2017, in a private investment in public entities, the Company entered into various purchase agreements with existing investors and issued 4,010,000 shares of the Company’s common stock in exchange for $401,000 in cash. And in January 2018, the Company entered into stock purchase agreements with existing investors and issued 7,182,818 shares of the Company’s common stock in exchange for $750,100 in cash.

In January 2018, the Company issued 50,000 shares of common stock to an existing investor in exchange for $6,425 in services rendered.

In the first quarter of 2018, the Company issued 12,314,291 shares of its common stock in exchange for redemption of certain convertible debt.

In March of 2018, the Company issued 4,285,423 shares of its common stock in exchange for payment of interest expense on certain long-term convertible debt.

Concurrently with the consummation of the preferred stock offering as more fully discussed in Note 10, in March 2018, the Company entered into share purchase agreements with certain institutional investors pursuant to which the Company issued 29,411,766 shares of the Company’s common stock in exhcnage for $5.0 million in cash.

As of March 31, 2018 and 2017, the Company had reserved shares of common stock for issuance as follows:

	March 31,	March 31,
	2018	2017
Options issued and outstanding	15,646,054	2,528,650
Options available for grant	30,986,066	362,700
RSUs issued and outstanding	5,893,849	20,789
Warrants issued and outstanding	4,820,025	6,339,792
Convertible notes	11,767,883	69,869

Total	69,113,877	9,321,800

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

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+ Details

Convertible Preferred Stock	3 Months Ended
Convertible Preferred Stock	Mar. 31, 2018
Convertible Preferred Stock
Convertible Preferred Stock	10. Convertible Preferred Stock The Company’s third amended and restated certificate of incorporation dated July 31, 2017 authorizes the Company to issue 10,000,000 shares of preferred stock $0.0001 par value. In March 2018, the Company entered into a stock purchase agreement with Sagard Capital Partners, L.P. pursuant to which the Company, in a private placement, agreed to issue and sell to Sagard 5,524,926 shares of the Company’s series A convertible participating preferred stock, $0.0001 par value per share, for an aggregate purchase price of $9,199,001. Each share of preferred stock is initially convertible into nine shares of common stock at the option of the holder at an effective conversion price of $0.185 per share (based on an original price per Preferred Share of $1.665), provided that, at any time prior to the time the Company obtains stockholder approval, as required pursuant to Nasdaq Rule 5635(b) any conversion of Preferred Stock by a holder into shares of the Common Stock would be prohibited if, as a result of such conversion, the holder, together with such holder’s attribution parties, would beneficially own more than 19.99% of the total number of shares of the Common Stock issued and outstanding after giving effect to such conversion. Subject to certain limited exceptions, the shares of Preferred Stock cannot be offered, pledged or sold by Sagard for one year from the date of issuance. The conversion price is subject to certain adjustments in the event of any stock dividend, stock split, reverse stock split, combination or other similar recapitalization. Holders of the Series A shares are entitled to participate equally and ratably with the holders of common stock shares in all dividends paid and distributions made to the holders of the common stock as if, immediately prior to each record date of the common stock, the shares of Series A then outstanding were converted into shares of common stock. In the event of any voluntary or involuntary liquidation, dissolution or winding up of the Company or deemed liquidation event, the holders of Series A shares then outstanding shall be entitled to be paid in cash out of the assets of the Company before any payment shall be made to the holders of common stock or shares of any series or class of preferred or other capital stock then outstanding that by its terms is junior to the Series A in respect of the preferences as to distributions and payments upon such liquidation event by reason of their ownership, an amount per share of Series A equal to one (1) times the Series A original issue price. The redemption and liquidation value of the series A preferred stock is $12,738,822 and $9,199,002, respectively. If a Redemption Event occurs as of the Measurement Date (the later of April 30, 2021 and the date on which the Company files its Form 10-Q for the three months ending March 31, 2021, but in no event later than June 30, 2021), the holders of at least a majority of the shares of Series A then outstanding may require the Company to redeem all Series A shares at a per share purchase price equal to $2.3057; any one of the following conditions can result in a Redemption Event that is not solely within the Company’s control: Revenues attributable to the Mytesi product for the six-month period ended March 31, 2021 are less than $22m or the average VWAP for the Company’s common stock for the 30 days prior to a Measurement Date is less than $1.00. The effective conversion price is $0.185 per share while the fair value of the Company’s common stock at the commitment date was $0.205 per share based on the closing price of common stock on March 23, 2018. As a result, the Company determined that there is a Beneficial Conversion Feature (“BCF”) amounting to approximately $995,000, which is computed by taking the difference between the closing price of the stock on March 23, 2018 and the conversion price multiplied by the as if converted 49,724,334 shares (5,524,926 preferred shares multiplied by the conversion factor of 9). The Company’s Series A shares do not have a stated conversion date and are immediately convertible at the issuance date. As such, the Company will record an accretion of the BCF to net loss. Based on the guidance above, the Company recorded a deemed dividend charge of $995,000 for the accretion of the discount on the Series A shares. The deemed dividend was a non-cash transaction and is reflected below net loss to arrive at net loss available to common stockholders on the Company’s condensed consolidated statement of operations for the three months ended March 31, 2018. As of March 31, 2018, there were 5,524,926 and 0 shares of convertible preferred stock were issued and outstanding at March 31, 2018 and December 31, 2017. The preferred stock has been classified outside of stockholders’ equity in accordance with authoritative guidance for the classification and measurement of potentially redeemable securities.

Stock Incentive Plans

3 Months Ended

Mar. 31, 2018

Stock Incentive Plans

11. Stock Incentive Plans

2013 Equity Incentive Plan

Effective November 1, 2013, the Company’s board of directors and sole stockholder adopted the Jaguar Health, Inc. 2013 Equity Incentive Plan (the “2013 Plan”). The 2013 Plan allows the Company’s board of directors to grant stock options, restricted stock awards and restricted stock unit awards to employees, officers, directors and consultants of the Company. As of December 31, 2013, the Company had reserved 300,000 shares of its common stock for issuance under the 2013 Plan. In April 2014, the board of directors amended the 2013 Plan to increase the shares reserved for issuance to 847,533 shares. Following the effective date of the IPO and after effectiveness of any grants under the 2013 Plan that were contingent on the IPO, no additional stock awards will be granted under the 2013 Plan. Outstanding grants continue to be exercisable, however any unissued shares under the plan and any forfeitures of outstanding options do not rollover to the 2014 Stock Incentive Plan. There were 565,377 option shares outstanding at December 31, 2017.

2014 Stock Incentive Plan

Effective May 12, 2015, the Company adopted the Jaguar Health, Inc. 2014 Stock Incentive Plan (“2014 Plan”). The 2014 Plan provides for the grant of options, restricted stock and restricted stock units to eligible employees, directors and consultants to purchase the Company’s common stock. The Company reserved 333,333 shares of common stock for issuance pursuant to the 2014 Plan. On January 1, 2018, 2017 and 2016, the Company added 2,106,507, and 280,142, and 162,498 shares to the option pool in accordance with the 2014 Plan that provides for automatic share increases on the first day of each fiscal year in the amount of 2% of the outstanding number of shares of the Company’s common stock on last day of the preceding calendar year. The 2014 Plan replaces the 2013 Plan except that all outstanding options under the 2013 Plan remain outstanding until exercised, cancelled or until they expire.

In July 2015, the Company amended the 2014 Plan reserving an additional 550,000 shares under the plan contingent upon approval by the Company’s stockholders at the June 2016 annual stockholders meeting. In June 2016, the Company amended the 2014 Plan once again, modifying the increase from 550,000 shares to 1,550,000 shares, which was approved at the 2016 annual stockholders meeting. In July 2017, the Company amended the 2014 Plan reserving an additional 6,500,188 shares under the plan, which was approved at the special stockholders meeting on July 27, 2017.

In March 2018, the Company amended the 2014 Plan reserving an additional 41,060,000 shares under the plan.

Stock Options and Restricted Stock Units (“RSUs”)

The following table summarizes incentive plan activity for the years ended March 31, 2018 and December 31, 2017:

						Weighted		Weighted Average	Aggregate
	Shares					Average		Remaining	Intrinsic
	Available		Stock Options		RSUs	Stock Option		Contractual Life	Value
	for Grant		Outstanding		Outstanding	Exercise Price		(Years)	*
Combined Incentive Plan Balance—December 31, 2017	53,026		3,444,663		5,893,849	$	1.87	8.31	$	—


Additional shares authorized	43,166,507
Options granted	(12,767,961	)	12,767,961
Options cancelled	534,494		(566,570	)


Combined Incentive Plan Balance—March 31, 2018	30,986,066		15,646,054		5,893,849	$	0.84	1.65	$	51,247

Options vested and exercisable—March 31, 2018			1,615,043			$	3.06	3.06	$	49,927

Options vested and expected to vest—March 31, 2018			12,711,812			$	0.88	9.07	$	50,902

Fair market value of JAGX stock on March 29 (31), 2018 was $0.195 per share.

The weighted average grant date fair value of stock options granted was $0.17 and $0.46 per share during the three months ended March 31, 2018 and 2017.

The number of option shares that vested in the three months ended March 31, 2018 and 2017 was 3,525,395 shares and 185,005 shares, respectively. The grant date weighted average fair value of option shares that vested in the three months ended March 31, 2018 and 2017 was $251,060 and $185,646, respectively.

No options were exercised in the three months ended March 31, 2018 and 2017.

The intrinsic value is computed as the options granted multiplied by the difference between the fair market value of the Company’s common stock of $0.195 on March 31, 2018 and the grant date stock option exercise price.

Stock-Based Compensation

The following table summarizes stock-based compensation expense related to stock options and RSUs for the three months ended March 31, 2018 and 2017, and are included in the statements of operations and comprehensive loss as follows:

	Three Months Ended
	March 31,
	2018		2017
Research and development expense	$	79,714	$	65,799
Sales and marketing expense	2,385		7,658
General and administrative expense	190,144		154,579

Total	$	272,243	$	228,036

As of March 31, 2018, the Company had $1,922,627 of unrecognized stock-based compensation expense for options and restricted stock units outstanding, which is expected to be recognized over a weighted-average period of 2.11 years.

The estimated grant-date fair value of employee stock options was calculated using the Black-Scholes-Merton option-pricing model using the following assumptions:

	Three Months Ended
	March 31,
	2018	2017
Weighted-average volatility	87.38-92.42%	74.26	%
Weighted-average expected term (years)	5.07-5.82	5.82
Risk-free interest rate	2.58-2.65%	1.98	%
Expected dividend yield	—	—

The estimated grant-date fair value of non-employee stock options was calculated using the Black-Scholes-Merton option-pricing model was revalued using the following assumptions:

	Three Months Ended
	March 31,
	2018	2017
Weighted-average volatility	85.29-89.5%	—
Weighted-average expected term (years)	9.55-9.75	—
Risk-free interest rate	2.63-2.86%	—
Expected dividend yield	—	—

Net Loss Per Share Attributable to Common Stockholders

The entire disclosure for compensation-related costs for equity-based compensation, which may include disclosure of policies, compensation plan details, allocation of equity compensation, incentive distributions, equity-based arrangements to obtain goods and services, deferred compensation arrangements, employee stock ownership plan details and employee stock purchase plan details.

+ References + Details

Net Loss Per Share Attributable to Common Stockholders

3 Months Ended

Mar. 31, 2018

Net Loss Per Share Attributable to Common Stockholders

12. Net Loss Per Share Attributable to Common Stockholders

The following table presents the calculation of basic and diluted net loss per common share for the three months ended March 31, 2018 and 2017:

	Three Months Ended
	March 31,			March 31,
	2018			2017
Net loss attributable to common shareholders	$	(6,691,637	)	$	(4,715,358	)

Shares used to compute net loss per common share, basic and diluted	129,467,132			14,157,351

Net loss per share attributable to common shareholders, basic and diluted	$	(0.05	)	$	(0.33	)

Basic net loss per share is calculated by dividing net loss by the weighted-average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing net loss by the weighted-average number of common shares and common share equivalents outstanding for the period. Common stock equivalents are only included when their effect is dilutive. The Company’s potentially dilutive securities which include stock options, convertible preferred stock and common stock warrants have been excluded from the computation of diluted net loss per share as they would be anti-dilutive. For all periods presented, there is no difference in the number of shares used to compute basic and diluted shares outstanding due to the Company’s net loss position.

The following outstanding common stock equivalents have been excluded from diluted net loss per common share for the three months ended March 31, 2018 and 2017 because their inclusion would be anti-dilutive:

	March 31,	March 31,
	2018	2017
Options issued and outstanding	15,646,054	2,528,650
Warrants to purchase common stock	4,820,025	6,339,792
Restricted stock units	5,893,849	20,789

Total	26,359,928	8,889,231

Income Taxes	3 Months Ended
Income Taxes	Mar. 31, 2018
Income Taxes
Income Taxes	13. Income Taxes The forecasted effective tax rate for the three months ended March 31, 2018 and 2017 was zero percent, primarily as a result of the estimated tax loss for the year and the change in valuation allowance.

401(k) Plan	3 Months Ended
401(k) Plan	Mar. 31, 2018
401(k) Plan
401(k) Plan	14. 401(k) Plan The Company sponsors a 401(k) defined contribution plan covering all employees. There were no employer contributions to the plan from plan inception through March 31, 2018.

Subsequent Events	3 Months Ended
Subsequent Events	Mar. 31, 2018
Subsequent Events
Subsequent Events	15. Subsequent Events In April of 2018, the Company issued 2,034,082 shares of common stock in exchange for $203,000 of proceeds which were used to pay off the $150,000 principal balance and $53,000 of unpaid accrued interest on the February 2015 convertible debt.

Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2018

Summary of Significant Accounting Policies

Basis of Presentation

Principles of Consolidation

Use of Estimates

Concentration of Credit Risk and Cash and Cash Equivalents

Fair Values

Restricted Cash

Inventories

Land, Property and Equipment

Land is stated at cost, reflecting fair value of the property at July 31, 2017, the date of the merger with Napo.

Long-Lived Assets

Definite-lived intangible assets are amortized on a straight-line basis over the estimated periods benefited, and are reviewed regularly for possible impairment.

Goodwill and Indefinite-lived Intangible Assets

Research and Development Expense

Revenue Recognition

Contracts

Performance obligations

Transaction price

Allocate transaction price

For both Napo and Jaguar, the entire transaction price is allocated to the single performance obligaton contained in each contract.

Point in time recognition

Disaggregation of Product Revenue

Human

Animal

Collaboration Revenue

Stock-Based Compensation

The Company’s 2013 Equity Incentive Plan and 2014 Stock Incentive Plan (see Note 10) provides for the grant of stock options, restricted stock and restricted stock unit awards.

Classification of Securities

Income Taxes

Comprehensive Loss

Segment Data

The Company’s reportable segments net sales and net income consisted of:

	Three Months Ended March 31,
	2018			2017
Revenue from external customers
Human Health	$	583,269		$	—
Animal Health	43,698			822,410

Consolidated Totals	$	626,967		$	822,410

Interest expense
Human Health	$	105,891		$	—
Animal Health	496,131			180,072

Consolidated Totals	$	602,022		$	180,072

Depreciation and amortization
Human Health	$	314,530		$	—
Animal Health	15,031			15,031

Consolidated Totals	$	329,561		$	15,031

Segment profit
Human Health	$	(2,899,306	)	$	—
Animal Health	(2,797,331		)	(4,715,358		)

Consolidated Totals	$	(5,696,637	)	$	(4,715,358	)

The Company’s reportable segments assets consisted of the following:

	As of March 31,		As of December 31,
	2018		2017
Segment assets
Human Health	$	41,520,244	$	41,754,603
Animal Health	50,982,480		36,807,184

Total	$	92,502,724	$	78,561,787

The reconciliation of segments assets to the consolidated assets is as follows:

	As of March 31,			As of December 31,
	2018			2017
Total assets for reportable segments	$	92,502,724		$	78,561,787
Less: investment in subsidiary	(29,240,965		)	(29,240,965		)
Less: Intercompany loan	(2,000,000		)	(2,000,000		)
Less: intercompany receivable	(10,994,417		)	(3,691,616		)

Consolidated Totals	$	50,267,342		$	43,629,206

Basic and Diluted Net Loss Per Common Share

Recent Accounting Pronouncements

Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2018

Summary of Significant Accounting Policies

Schedule of reportable segments net sales and net income

	Three Months Ended March 31,
	2018			2017
Revenue from external customers
Human Health	$	583,269		$	—
Animal Health	43,698			822,410

Consolidated Totals	$	626,967		$	822,410

Interest expense
Human Health	$	105,891		$	—
Animal Health	496,131			180,072

Consolidated Totals	$	602,022		$	180,072

Depreciation and amortization
Human Health	$	314,530		$	—
Animal Health	15,031			15,031

Consolidated Totals	$	329,561		$	15,031

Segment profit
Human Health	$	(2,899,306	)	$	—
Animal Health	(2,797,331		)	(4,715,358		)

Consolidated Totals	$	(5,696,637	)	$	(4,715,358	)

Schedule of reportable segments assets

	As of March 31,		As of December 31,
	2018		2017
Segment assets
Human Health	$	41,520,244	$	41,754,603
Animal Health	50,982,480		36,807,184

Total	$	92,502,724	$	78,561,787

Schedule of reconciliation of segments assets to the consolidated assets

	As of March 31,			As of December 31,
	2018			2017
Total assets for reportable segments	$	92,502,724		$	78,561,787
Less: investment in subsidiary	(29,240,965		)	(29,240,965		)
Less: Intercompany loan	(2,000,000		)	(2,000,000		)
Less: intercompany receivable	(10,994,417		)	(3,691,616		)

Consolidated Totals	$	50,267,342		$	43,629,206

Business Combination (Tables)

3 Months Ended

Mar. 31, 2018

Business Combination

Schedule of total consideration exchanged

	(Unaudited)
Fair value of Jaguar common stock	$	25,303,859
Fair value of Jaguar common stock warrants	630,859
Fair value of replacement restricted stock units	3,300,555
Fair value of replacement stock options	5,691
Cash	2,000,000
Effective settlement of receivable from Napo	464,295

Total consideration exchanged	$	31,705,259

Schedule of purchase price allocation to assets and liabilities assumed in the transaction

Current assets	$	2,578,114
Non-current assets	396,247
Identifiable intangible assets	36,400,000
Current liabilities	(4,052,180		)
Convertible notes payable	(12,473,501		)
Deferred tax liability	(13,181,242		)

Net assets acquired	9,667,438
Goodwill on acquisition	22,037,821

Total consideration	$	31,705,259

Schedule of unaudited proforma results

	For the Three Months Ended March 31,
	2018		2017
Net sales	804,356		1,340,544
Net loss	(5,696,637	)	(7,647,024	)
Net loss per share, basic and diluted	(0.04	)	(0.54	)

Fair Value Measurements (Tables)

3 Months Ended

Mar. 31, 2018

Fair Value Measurements

Summary of information about the derivative, conversion option and warrant liability that is measured at fair value on a recurring basis

	March 31, 2018
	Level 1		Level 2		Level 3		Total
Warrant liability	$	—	$	—	$	192,960	$	192,960
Derivative liability	—		—		15,000		15,000
Conversion option liability	—		—		—		—

Total fair value	$	—	$	—	$	207,960	$	207,960

	December 31, 2017
	Level 1		Level 2		Level 3		Total
Warrant liability	$	—	$	—	$	103,860	$	103,860
Derivative liability	—		—		11,000		11,000
Conversion option liability	—		—		111,841		111,841

Total fair value	$	—	$	—	$	226,701	$	226,701

Summary of change in the estimated fair value of level 3 liabilities

	For The Three Months Ended
	March 31, 2018							March 31, 2017
	Warrant		Derivative		Conversion Option			Warrant
	liability		Liability		Liability			liability
Beginning fair value of level 3 liability	$	103,860	$	11,000	$	111,841		$	799,201
Extinguishment	—		—		(286,595		)	—
Change in fair value of level 3 liability	89,100		4,000		174,754			453,419

Ending fair value of level 3 liability	$	192,960	$	15,000	$	—		$	1,252,620

Related Party Transactions (Tables)

3 Months Ended

Mar. 31, 2018

Related Party Transactions

Summary of outstanding receivables (payables) from Napo

	March 31,
	2017
Due from former parent	$	221,429
Royalty payable to former parent	(7		)

Net receivable (payable) to former parent	$	221,422

Balance Sheet Components (Tables)

3 Months Ended

Mar. 31, 2018

Balance Sheet Components

Schedule of Land, property and equipment

	March 31,			December 31,
	2018			2017
Land	$	396,247		$	396,247
Lab equipment	811,087			811,087
Clinical equipment	64,870			64,870
Software	62,637			62,637
Furniture and fixtures	6,527			—

Total property and equipment at cost	1,341,368			1,334,841
Accumulated depreciation	(127,804		)	(112,773		)

Property and equipment, net	$	1,213,564		$	1,222,068

Schedule of depreciation expense

	Three Months Ended
	March 31,
	2018		2017
Depreciation - lab equipment - research and development expense	$	6,568	$	6,568
Depreciation - clinical equipment - research and development expense	3,243		3,243
Depreciation - software - general and administrative expense	5,220		5,220

Total depreciation expense	$	15,031	$	15,031

Schedule of change in the carrying amount of goodwill

	March 31,		December 31,
	2018		2017
Beginning balance	$	5,210,821	$	—
Goodwill acquired in conjunction with the Napo merger	—		22,037,821
Impairment	—		(16,827,000		)

Ending balance	5,210,821		5,210,821

Schedule of intangible assets

	March 31,			December 31,
	2018			2017
Developed technology	$	25,000,000		$	25,000,000
Accumulated developed technology amortization	(1,111,112		)	(694,445		)

Developed technology, net	23,888,888			24,305,555

In process research and development	11,100,000			11,100,000
Impairment	(2,300,000		)	(2,300,000		)

	8,800,000			8,800,000

Trademarks	300,000			300,000
Accumulated trademark amortization	(13,333		)	(8,333		)

Trademarks, net	286,667			291,667

Total intangible assets, net	$	32,975,555		$	33,397,222

Schedule of accrued expenses

	March 31,		December 31,
	2018		2017
Accrued compensation and related:
Accrued vacation	$	287,522	$	264,304
Accrued payroll	1,150		150
Accrued payroll tax	28,016		30,617

	316,688		295,071
Accrued interest	342,498		659,961
Accrued research and development costs	668,850		668,850
Accrued audit	6,250		40,000
Accrued other	329,948		535,667

Total	$	1,664,234	$	2,199,549

Commitments and Contingencies (Tables)

3 Months Ended

Mar. 31, 2018

Commitments and Contingencies

Schedule of future minimum lease payments under noncancelable operating leases

Future minimum lease payments under non-cancelable operating leases as of December 31, 2017 are as follows:

Years ending December 31,	Amount
2018	$	153,705

Total minimum lease payments	$	153,705

Debt and Warrants (Tables)

3 Months Ended

Mar. 31, 2018

Schedule of aggregate convertible notes payable obligations

	March 31,			December 31,
	2018			2017
February 2015 convertible notes payable	150,000			150,000
June 2017 convertible note payable	683,585			1,613,089
Napo convertible notes	10,875,300			12,153,389

	$	11,708,885		$	13,916,478
Less: unamortized debt discount and debt issuance costs	(142,902		)	(261,826		)

Net convertible notes payable obligation	$	11,565,983		$	13,654,652


Convertible notes payable - non-current	10,875,300			10,982,437

Convertible notes payable - current	$	690,683		$	2,672,215

Schedule of interest expense on convertible notes

	Three Months Ended
	March 31,
	2018		2017
February 2015 convertible note nominal interest	$	4,438	$	4,438
June 2017 convertible note nominal interest	18,864		—
June 2017 convertible note accretion of debt discount	118,923		—
Napo convertibles note nominal interest	87,828		—

Total interest expense on convertible debt	$	230,053	$	4,438

Schedule of long-term debt obligation

	March 31,		December 31,
	2018		2017
Debt and unpaid accrued end-of-term payment	$	—	$	1,636,639
Unamortized note discount	—		(6,615		)
Unamortized debt issuance costs	—		(20,780		)

Net debt obligation	$	—	$	1,609,244


Current portion of long-term debt	$	—	$	1,609,244
Long-term debt, net of discount	—		—

Total	$	—	$	1,609,244

Schedule of interest expense on long-term debt

	Three Months Ended
	March 31,
	2018		2017
Nominal interest	$	19,344	$	78,861
Accretion of debt discount	20,779		11,678
Accretion of end-of-term payment	52,561		48,655
Accretion of debt issuance costs	6,616		36,439

	$	99,300	$	175,633

Schedule of short-term debt obligations

	Notes Payable
	March 31,			December 31,
	2018			2017
December 2017 note payable	$	1,587,500		$	1,587,500
February 2018 note payable	2,240,909			—
March 2018 note payable	1,090,341			—

	4,918,750			1,587,500
Less: unamortized net discount and debt issuance costs	(1,262,651		)	(446,347		)

Net convertible notes payable obligation	$	3,656,099		$	1,141,153

Schedule of interest expense on short term debt

	Three Months Ended
	March 31,
	2018		2017
Nominal interest	$	49,659	$	—
Accretion of debt discount	204,946		—

Total interest expense on notes payable	$	254,605	$	—

Summary of warrant activity

	Three Months Ended	Year Ended
	March 31,	December 31,
	2018	2017
	(in shares)
Beginning balance	4,820,025	5,968,876
Warrants granted	—	1,595,791
Warrants exercised	—	(908,334	)
Warrants cancelled	—	(1,836,308	)

Ending balance	4,820,025	4,820,025

Schedule of common reserved shares of common stock for issuance

Tabular disclosure of long-debt instruments or arrangements, including identification, terms, features, collateral requirements and other information necessary to a fair presentation. These are debt arrangements that originally required repayment more than twelve months after issuance or greater than the normal operating cycle of the entity, if longer.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21475-112644

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 470
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6479336&loc=d3e64711-112823

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(e),(f))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 55
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=64930739&loc=d3e28878-108400

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21538-112644

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21506-112644

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 45
-Paragraph 1A
-URI http://asc.fasb.org/extlink&oid=64930785&loc=d3e28541-108399

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 45
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=64930785&loc=d3e28551-108399

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 7
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21521-112644

+ Details

Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2018

Stockholders' Equity

	March 31,	March 31,
	2018	2017
Options issued and outstanding	15,646,054	2,528,650
Options available for grant	30,986,066	362,700
RSUs issued and outstanding	5,893,849	20,789
Warrants issued and outstanding	4,820,025	6,339,792
Convertible notes	11,767,883	69,869

Total	69,113,877	9,321,800

Stock Incentive Plans (Tables)

3 Months Ended

Mar. 31, 2018

Summary of incentive plan activity

						Weighted		Weighted Average	Aggregate
	Shares					Average		Remaining	Intrinsic
	Available		Stock Options		RSUs	Stock Option		Contractual Life	Value
	for Grant		Outstanding		Outstanding	Exercise Price		(Years)	*
Combined Incentive Plan Balance—December 31, 2017	53,026		3,444,663		5,893,849	$	1.87	8.31	$	—


Additional shares authorized	43,166,507
Options granted	(12,767,961	)	12,767,961
Options cancelled	534,494		(566,570	)


Combined Incentive Plan Balance—March 31, 2018	30,986,066		15,646,054		5,893,849	$	0.84	1.65	$	51,247

Options vested and exercisable—March 31, 2018			1,615,043			$	3.06	3.06	$	49,927

Options vested and expected to vest—March 31, 2018			12,711,812			$	0.88	9.07	$	50,902

Fair market value of JAGX stock on March 29 (31), 2018 was $0.195 per share.

Summary of stock-based compensation expense

	Three Months Ended
	March 31,
	2018		2017
Research and development expense	$	79,714	$	65,799
Sales and marketing expense	2,385		7,658
General and administrative expense	190,144		154,579

Total	$	272,243	$	228,036

Employee stock options

Schedule of estimated grant-date fair value of stock options calculated using the Black-Scholes option-pricing model

	Three Months Ended
	March 31,
	2018	2017
Weighted-average volatility	87.38-92.42%	74.26	%
Weighted-average expected term (years)	5.07-5.82	5.82
Risk-free interest rate	2.58-2.65%	1.98	%
Expected dividend yield	—	—

Non-employee stock options

Schedule of estimated grant-date fair value of stock options calculated using the Black-Scholes option-pricing model

	Three Months Ended
	March 31,
	2018	2017
Weighted-average volatility	85.29-89.5%	—
Weighted-average expected term (years)	9.55-9.75	—
Risk-free interest rate	2.63-2.86%	—
Expected dividend yield	—	—

Net Loss Per Share Attributable to Common Stockholders (Tables)

3 Months Ended

Mar. 31, 2018

Net Loss Per Share Attributable to Common Stockholders

Schedule of calculation of basic and diluted net loss per common share

	Three Months Ended
	March 31,			March 31,
	2018			2017
Net loss attributable to common shareholders	$	(6,691,637	)	$	(4,715,358	)

Shares used to compute net loss per common share, basic and diluted	129,467,132			14,157,351

Net loss per share attributable to common shareholders, basic and diluted	$	(0.05	)	$	(0.33	)

Schedule of common stock equivalents excluded from the calculation of diluted net loss per common share

	March 31,	March 31,
	2018	2017
Options issued and outstanding	15,646,054	2,528,650
Warrants to purchase common stock	4,820,025	6,339,792
Restricted stock units	5,893,849	20,789

Total	26,359,928	8,889,231

Organization and Business - (Details)		3 Months Ended	12 Months Ended
Organization and Business - (Details)	Jun. 11, 2013 shares	Mar. 31, 2018 segment	Dec. 31, 2016 segment
Organization and Business
Number of segments \| segment		2	1
Stock issued in exchange for cash and services (in shares) \| shares	2,666,666

Organization and Business - Liquidity (Details) - USD ($)

1 Months Ended

2 Months Ended

3 Months Ended

Jul. 31, 2017

Jun. 28, 2017

May 08, 2017

Apr. 30, 2018

Mar. 31, 2018

Jan. 31, 2018

Dec. 31, 2017

Nov. 30, 2017

Jun. 30, 2016

Mar. 31, 2018

Dec. 31, 2017

Mar. 31, 2018

Accumulated deficit

$ (68,101,359)

$ (62,404,722)

^[1]

$ (68,101,359)

$ (62,404,722)

^[1]

$ (68,101,359)

Shares issued (in shares)

2,034,082

4,285,423

2,444,486

6,000,000

Proceeds from issuance of common stock

$ 203,000

$ 5,000,000

$ 5,063,785

Maximum number of shares company is permitted to issue

2,027,490

Maximum number of shares company is permitted to issue (as a percent)

19.99%

Common Stock

Shares issued (in shares)

29,411,766

50,000

235,134

9,746,413

6,492,084

12,314,291

Proceeds from issuance of common stock

$ 6,425

$ 43,829

$ 900,362

Common Stock | Private investment

Maximum committed purchase of common stock by investor

$ 15,000,000

Agreement term (in months)

30 months

Shares issued (in shares)

3,243,243

100,000

3,555,514

4,010,000

5,100,000

Proceeds from issuance of common stock

$ 3,000,000

$ 50,000

$ 401,000

$ 555,262

Share price required to issue shares more than permitted number (in dollars per share)

$ 1.32

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Summary of Significant Accounting Policies - Restricted Cash (Details) - USD ($)

Mar. 31, 2018

Dec. 31, 2017

^[1]

Mar. 31, 2017

Aug. 18, 2015

Restricted Cash

Maximum borrowing capacity

$ 8,000,000

Restricted cash, current

$ 0

$ 239,169

$ 21,192

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Summary of Significant Accounting Policies - Land, Property and Equipment and Goodwill and Indefinite-lived Intangible Assets (Details) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Goodwill impairment charges
Impairment of goodwill		$ 16,827,000
Impairment of long-lived intangible assets		$ 2,300,000
Equipment \| Minimum
Land, Property and Equipment
Estimated useful lives	3 years
Equipment \| Maximum
Land, Property and Equipment
Estimated useful lives	10 years

Summary of Significant Accounting Policies - Revenue Recognition (Details) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Disaggregation of Product Revenue
Product revenue	$ 626,967	$ 822,410
Mytesi
Disaggregation of Product Revenue
Product revenue	583,269	0
Neonorm
Disaggregation of Product Revenue
Product revenue	43,698	44,544
Botanical Extract
Disaggregation of Product Revenue
Product revenue	$ 0	$ 30,000
Napo \| M&D Agreement
Contracts
Term of agreement	4 years
Term of automatic renewal of agreement	1 year
Term of written notice of termination	90 days

Summary of Significant Accounting Policies - Revenue Recognition - Collaboration Revenue (Details) - USD ($)			3 Months Ended
	Nov. 01, 2017	Jan. 27, 2017	Mar. 31, 2018	Mar. 31, 2017
Collaboration Revenue
Written notice period (in days)	90 days
Elanco
Collaboration Revenue
Upfront payment received		$ 2,548,689
Product and development expense		1,048,689
Potential milestone payments		$ 61,000,000
Collaboration revenue			$ 177,389	$ 459,700
Upfront payment and expense reimbursement recognized as revenue			$ 0	$ 288,166
Estimated development period for revenue recognition (in years)			1 year

Summary of Significant Accounting Policies - Segment Data (Details)

3 Months Ended

12 Months Ended

Mar. 31, 2018

USD ($)

segment

Mar. 31, 2017

USD ($)

Dec. 31, 2016

segment

Dec. 31, 2017

USD ($)

Number of operations segments | segment

Number of reportable segments | segment

Revenue from external customer

$ 626,967

$ 822,410

Depreciation and amortization

(602,022)

(180,072)

329,561

15,031

Segment profit

(5,696,637)

(4,715,358)

50,267,342

$ 43,629,206

^[1]

Operating Segments

Segment Reconciling Items

92,502,724

78,561,787

Less: investment in subsidiary

(29,240,965)

Less: Intercompany loan

(2,000,000)

Less: intercompany receivable

(10,994,417)

(3,691,616)

Human Health

Revenue from external customer

583,269

Depreciation and amortization

105,891

314,530

Segment profit

(2,899,306)

41,520,244

41,754,603

Animal Health

Revenue from external customer

43,698

822,410

Depreciation and amortization

496,131

180,072

15,031

Segment profit

(2,797,331)

$ (4,715,358)

Purchase price allocation to assets and liabilities assumed

$ 50,982,480

$ 36,807,184

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Business Combination - Total consideration exchanged (Details) - Napo	Jul. 31, 2017 USD ($)
Total consideration exchanged
Fair value of Jaguar common stock	$ 25,303,859
Fair value of Jaguar common stock warrants	630,859
Fair value of replacement restricted stock units	3,300,555
Fair value of replacement stock options	5,691
Cash	2,000,000
Effective settlement of receivable from Napo	464,295
Total consideration exchanged	$ 31,705,259

Business Combination - Purchase price allocation to assets and liabilities assumed (Details) - USD ($)

3 Months Ended

12 Months Ended

Jul. 31, 2017

Mar. 31, 2018

Dec. 31, 2017

Goodwill on acquisition

$ 5,210,821

^[1]

Impairment of long-lived intangible assets

$ 2,300,000

Deferred tax asset

$ 1,316,878

Acquisition related costs

$ 3,554,250

Shares issued to creditors

270,270

Fair value of shares issued to creditors (in shares)

$ 151,351

Napo

Purchase price allocation to assets and liabilities assumed

Current assets

2,578,114

Non-current assets

396,247

Identifiable intangible assets

36,400,000

Current liabilities

(4,052,180)

Goodwill expected to be deductible for income tax purposes

(12,473,501)

Deferred tax liability

(13,181,242)

Net assets acquired

9,667,438

Goodwill on acquisition

22,037,821

Total consideration

31,705,259

Finished goods step-up

$ 84,806

Napo | Developed technology

Purchase price allocation to assets and liabilities assumed

Estimated useful life

15 years

Napo | Trademarks

Purchase price allocation to assets and liabilities assumed

Estimated useful life

15 years

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Business Combination - Unaudited proforma results (Details) - Napo - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Unaudited proforma results
Net sales	$ 804,356	$ 1,340,544
Net loss	$ (5,696,637)	$ (7,647,024)
Net loss per share, basic and diluted	$ (0.04)	$ (0.54)

Fair Value Measurements - Fair Value of Liabilities Measured on a Recurring Basis (Details) - Recurring - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Fair value of liabilities measured on a recurring basis
Total fair value	$ 207,960	$ 226,701
Level 3
Fair value of liabilities measured on a recurring basis
Total fair value	207,960	226,701
Warrant liability
Fair value of liabilities measured on a recurring basis
Total fair value	192,960	103,860
Warrant liability \| Level 3
Fair value of liabilities measured on a recurring basis
Total fair value	192,960	103,860
Derivative liability
Fair value of liabilities measured on a recurring basis
Total fair value	15,000	11,000
Derivative liability \| Level 3
Fair value of liabilities measured on a recurring basis
Total fair value	$ 15,000	11,000
Conversion option liability
Fair value of liabilities measured on a recurring basis
Total fair value		111,841
Conversion option liability \| Level 3
Fair value of liabilities measured on a recurring basis
Total fair value		$ 111,841

Fair Value Measurements - Estimated Fair Value of Warrant Liability (Details)

1 Months Ended

3 Months Ended

12 Months Ended

Mar. 23, 2018

$ / shares

Nov. 29, 2016

$ / shares

Dec. 31, 2017

USD ($)

$ / shares

Mar. 31, 2018

USD ($)

$ / shares

Mar. 31, 2017

USD ($)

tranche

Lender

Dec. 31, 2017

USD ($)

$ / shares

Jun. 30, 2017

USD ($)

Change in the estimated fair value of the warrant liability

Beginning value of warrant liability

^[1]

$ 103,860

Change in fair value of warrants

89,100

Ending Fair value of warrant liability

$ 103,860

^[1]

192,960

$ 103,860

^[1]

Fair Value Assumptions and Methodology for Assets and Liabilities

Change in fair value of warrants

$ 89,100

Warrant liability

Fair Value Assumptions and Methodology for Assets and Liabilities

Exercise price (in dollars per share) | $ / shares

$ 0.69

$ 0.1398

$ 0.195

$ 0.1398

$ 0.75

0.75

$ 0.75

5 years 6 months

4 years 1 month 28 days

4 years 4 months 28 days

71.92%

109.62%

96.36%

0.00%

1.87%

2.49%

2.14%

Fair Value Assumptions and Methodology for Assets and Liabilities

Fair value of derivative liability due to repayment of mandatory default

$ 15,000

Fair value of derivative liability due to interest rate increase feature

$ 5,000

Fair Value Assumptions and Methodology for Assets and Liabilities

$ 0.21

0.14

$ 0.14

1 month 10 days

288.16%

0.00%

Conversion price (in dollars per share) | $ / shares

1.69%

$ 0.20

Conversion option liability | Minimum

Fair Value Assumptions and Methodology for Assets and Liabilities

1 month 17 days

86.29%

Conversion option liability | Maximum

1.28%

Fair Value Assumptions and Methodology for Assets and Liabilities

3 months

160.78%

Conversion option liability | Exchangeable note purchase agreement

1.39%

Fair Value Assumptions and Methodology for Assets and Liabilities

Issuance of common stock in exchange for services (in shares) | shares

2,492,084

Partial redemption of convertible notes

$ 299,050

Napo

Fair Value Assumptions and Methodology for Assets and Liabilities

Fair Value Assumptions and Methodology for Assets and Liabilities

$ 0.56

Napo | Minimum

1 year 5 months 1 day

75.07%

Fair Value Assumptions and Methodology for Assets and Liabilities

1.28%

Napo | Maximum

8 years 5 months 1 day

110.03%

Napo | Exchangeable note purchase agreement

2.14%

Fair Value Assumptions and Methodology for Assets and Liabilities

Number of lenders | Lender

$ 0.5893

Face amount of each tranche

$ 1,312,500

Value of each tranche

525,000

$ 656,250

Conversion price (in dollars per share) | $ / shares

$ 0.56

$ 0.5600

$ 0.56

Napo | Conversion option liability | Exchangeable note purchase agreement

Fair Value Assumptions and Methodology for Assets and Liabilities

Number of lenders | Lender

Number of tranches | tranche

$ 1,312,500

Value of each tranche

$ 525,000

Face amount of each tranche

656,250

Percent of increase in the principal amount

12.00%

Conversion price (in dollars per share) | $ / shares

$ 0.20

Level 3 | Recurring | Warrant liability

Change in the estimated fair value of the warrant liability

Beginning fair value of level 3 liability

$ 103,860

799,201

$ 799,201

Change in fair value of level 3 liability

89,100

453,419

Ending fair value of level 3 liability

$ 103,860

192,960

1,252,620

103,860

Level 3 | Recurring | Derivative liability

Change in the estimated fair value of the warrant liability

Beginning fair value of level 3 liability

11,000

Issuance

20,000

Change in fair value of level 3 liability

4,000

9,000

Ending fair value of level 3 liability

11,000

15,000

11,000

Level 3 | Recurring | Conversion option liability

Change in the estimated fair value of the warrant liability

Beginning fair value of level 3 liability

$ 111,841

111,841

Extinguishment

(286,595)

Change in fair value of level 3 liability

$ 174,754

Ending fair value of level 3 liability

$ 111,841

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Related Party Transactions (Details) - Napo - USD ($)	3 Months Ended		12 Months Ended
Related Party Transactions (Details) - Napo - USD ($)	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2016
Related Party Transactions
Due from former parent		$ 221,429
Royalty payable to former parent		(7)
Net receivable (payable) to former parent		221,422
Loan receivable from related party	$ 2,000,000
Service Agreement
Related Party Transactions
Amount of share employee services and purchases on behalf of related party		407,267
Remittance from related party		465,625
Outstanding receivables	219,171
Purchase transactions
Related Party Transactions
Amount of share employee services and purchases on behalf of related party		5,376
Remittance from related party		$ 25,408
Outstanding receivables	$ 2,258		$ 22,290
Napo \| Service Agreement
Related Party Transactions
Amount of share employee services and purchases on behalf of related party			$ 277,529

Related Party Transactions - Royalty payable to former parent and license fee payable to former parent and related agreement (Details) - USD ($)		1 Months Ended						3 Months Ended
	Nov. 22, 2016	Apr. 30, 2018	Mar. 31, 2018	Jun. 30, 2016	Jan. 31, 2015	Jan. 31, 2014	Jul. 31, 2013	Mar. 31, 2018	Mar. 31, 2017	Mar. 31, 2016	Dec. 31, 2016
Commercialization Agreement
Shares issued (in shares)		2,034,082	4,285,423	2,444,486				6,000,000
Preferred stock, par value (in dollars per share)			$ 0.0001					$ 0.0001
Napo \| Option Agreement
Commercialization Agreement
License fees paid							$ 100,000
Term of agreement							2 years
Napo \| License Agreement
Commercialization Agreement
License fees paid										$ 425,000
Payment obligation of one-time non-refundable license fee					$ 1,750,000	$ 2,000,000
Option fee						100,000
Milestone payments due						$ 3,150,000
Royalty expiration term from the first sale of each individual product						10 years
Minimum proceeds from IPO prior to December 31, 2015, required for royalty reduction						$ 10,000,000
Milestone payments due in the event of minimum proceeds from IPO						$ 0
Napo \| License Agreement \| Current assets
Commercialization Agreement
Unpaid royalties			$ 7					$ 7			$ 171
Napo \| License Agreement \| Sales and marketing expense
Commercialization Agreement
Royalties incurred									$ 284
Royalties paid									$ 447
Products derived from Croton Lechleri \| Napo \| License Agreement
Commercialization Agreement
Royalty rate for net sales below revenue base (as a percent)						8.00%
Net product sales upon which royalty rate increases						$ 30,000,000
Royalty rate for net sales above revenue base (as a percent)						10.00%
Royalties payments due in the event of minimum proceeds from IPO						$ 0
Prescription products derived from Croton Lechleri \| Napo \| License Agreement
Commercialization Agreement
Royalty rate in the event of an IPO in excess of a specified amount						2.00%
Nonprescription products derived from Croton Lechleri \| Napo \| License Agreement
Commercialization Agreement
Royalty rate in the event of an IPO in excess of a specified amount						1.00%
Pharmaceutical prescription products not derived from Croton Lechleri \| Napo \| License Agreement
Commercialization Agreement
Royalty on annual net sales of products (as a percent)						2.00%
Nonprescription products not derived from Croton Lechleri \| Napo \| License Agreement
Commercialization Agreement
Royalty on annual net sales of products (as a percent)						1.00%
Sagard Capital Partners, L.P.
Commercialization Agreement
Consulting and management advisory services fees			450,000
Maximum aggregate payments for consulting and management advisory services received			$ 1,350,000
Private Placement
Commercialization Agreement
Shares issued (in shares)	1,666,668
Amount of shares issued	$ 1,000,000
Private Placement \| Series A convertible participating preferred stock \| Sagard Capital Partners, L.P.
Commercialization Agreement
Shares issued (in shares)			5,524,926
Preferred stock, par value (in dollars per share)			$ 0.0001					$ 0.0001
Amount of shares issued			$ 9,199,001

Balance Sheet Components - Land, Property and Equipment (Details) - USD ($)

3 Months Ended

Mar. 31, 2018

Mar. 31, 2017

Dec. 31, 2017

Land

$ 396,247

Property and equipment, net

1,341,368

1,334,841

Accumulated depreciation

(127,804)

(112,773)

1,213,564

1,222,068

^[1]

329,561

$ 15,031

Animal Health

15,031

Lab equipment

Lab equipment | Animal Health

811,087

6,568

Clinical equipment

Clinical equipment | Animal Health

64,870

3,243

Software

62,637

$ 62,637

Software | Animal Health

5,220

$ 5,220

Furniture and fixtures

Goodwill acquired in conjunction with the Napo merger

$ 6,527

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Balance Sheet Components - Goodwill (Details)

12 Months Ended

Dec. 31, 2017

USD ($)

Goodwill

$ 22,037,821

Impairment

(16,827,000)

Goodwill at end of the period

$ 5,210,821

^[1]

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Balance Sheet Components - Intangible assets (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017
Intangible assets
Impairment			$ 2,300,000
Total intangible assets, net	$ 32,975,555		33,397,222
Amortization expense	421,667	$ 0
Developed technology
Intangible assets
Total intangible assets	25,000,000		25,000,000
Less: Accumulated amortization	(1,111,112)		(694,445)
Total intangible assets, net	23,888,888		24,305,555
In process research and development
Intangible assets
Total intangible assets	11,100,000		11,100,000
Impairment	(2,300,000)		(2,300,000)
Total intangible assets, net	8,800,000		8,800,000
Trademarks
Intangible assets
Total intangible assets	300,000		300,000
Less: Accumulated amortization	(13,333)		(8,333)
Total intangible assets, net	$ 286,667		$ 291,667

Balance Sheet Components - Accrued Expenses (Details) - USD ($)

Mar. 31, 2018

Dec. 31, 2017

Accrued compensation and related:

Accrued vacation

$ 287,522

$ 264,304

Accrued payroll

1,150

150

Accrued payroll tax

28,016

30,617

Total of accrued compensation and related

316,688

295,071

Accrued interest

342,498

659,961

Accrued research and development costs

668,850

Accrued audit

6,250

40,000

Accrued other

329,948

535,667

$ 1,664,234

$ 2,199,549

^[1]

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Commitments and Contingencies - Operating Leases (Details) - USD ($)			3 Months Ended
	Dec. 14, 2017	Sep. 25, 2017	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017	Jul. 01, 2015
Commitments and Contingencies
Cash deposits under non-cancelable sub-lease agreement						$ 122,163
Security deposit under non-cancelable sub-lease agreement						29,539
Future minimum lease payments under non-cancellable operating leases
2018					$ 153,705
Total minimum lease payments					$ 153,705
Percentage of amount received to be paid to Glenmark		25.00%
Maximum amount to be received by Glenmark		$ 7,000,000
Non-cancelable purchase orders			$ 1,300,000
SEED
Future minimum lease payments under non-cancellable operating leases
Percentage of revenue sharing commitment	15.00%
Percentage of revenue sharing commitment after first million dollars of revenue	20.00%
Prepaid expenses and other current assets
Commitments and Contingencies
Prepayment of last three months lease payments						$ 92,623
General and administrative expense
Commitments and Contingencies
Rent expense under non-cancelable operating lease			$ 90,278	$ 90,278

Debt and Warrants - Convertible Notes (Details) - USD ($)

3 Months Ended

Mar. 31, 2018

Mar. 31, 2017

Dec. 31, 2017

Jul. 31, 2016

Less: unamortized debt discount and debt issuance costs

$ 11,708,885

$ 13,916,478

(142,902)

(261,826)

Net convertible notes payable obligation

11,565,983

13,654,652

Convertible notes payable - non-current

10,875,300

10,982,437

Convertible notes payable - current

690,683

2,672,215

^[1]

Total interest expense on convertible debt

(107,167)

230,053

$ 4,438

February 2015 Convertible Note

Convertible notes payable - current

150,000

$ 150,000

4,438

$ 4,438

683,585

1,613,089

18,864

118,923

Napo convertible notes

10,875,300

$ 12,153,389

$ 87,828

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Debt and Warrants - February 2015 Convertible Note (Details)

1 Months Ended

3 Months Ended

Jan. 31, 2017

USD ($)

$ / shares

Apr. 30, 2018

May 31, 2015

USD ($)

Feb. 28, 2015

USD ($)

item

$ / shares

Mar. 31, 2018

USD ($)

Mar. 31, 2017

USD ($)

Dec. 31, 2017

USD ($)

^[1]

Nov. 08, 2016

$ / shares

Jul. 31, 2016

USD ($)

Number of warrants issued to purchase shares of common stock (in shares) | shares

11,767,883

69,869

$ 690,683

$ 2,672,215

602,022

$ 180,072

207,713

February 2015 Convertible Note

15,489

Number of accredited investors | item

Number of warrants issued to purchase shares of common stock (in shares) | shares

$ 250,000

22,320

Exercise price (in dollars per share) | $ / shares

$ 5.60

Principal and interest paid on debt

$ 103,912

Retirement of convertible promissory notes

$ 100,000

$ 150,000

Convertible promissory note issued to Serious Change II LP

12.00%

Number of warrants issued to purchase shares of common stock (in shares) | shares

370,916

120,000

Exercise price (in dollars per share) | $ / shares

$ 0.51

$ 0.01

Share issued for principal and interest payment | shares

$ 207,713

2,034,082

Convertible promissory note issued to Serious Change II LP | Interest Expense

Accrued expenses | Convertible promissory note issued to Serious Change II LP

4,438

Current liabilities | Convertible promissory note issued to Serious Change II LP

$ 56,367

38,367

$ 150,000

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Debt and Warrants - June 2017 Convertible Note (Details) - USD ($)

3 Months Ended

Jun. 29, 2017

Mar. 31, 2018

Mar. 31, 2017

Dec. 31, 2017

Jun. 30, 2017

$ 15,489

Amortization of debt discount

602,022

$ 180,072

(107,167)

Change in fair value of derivative liability

15,000

$ 11,000

^[1]

4,000

690,683

2,672,215

^[1]

$ 2,155,000

$ 425,000

Proceeds from issuance of convertible debt

8.00%

Debt legal fee

$ 30,000

$ 1,700,000

Amortization of debt discount

121,018

118,228

118,923

Debt instrument, frequency of periodic payment

$ 1.00

monthly

Debt instrument, periodic payment

$ 350,000

Automatic increase in interest rate at the event of default

17.00%

June 2017 Convertible Note | Interest Expense

20,000

Amortization of debt discount

18,864

118,923

June 2017 Convertible Note | Other income and expense

Change in fair value of derivative liability

(4,000)

June 2017 Convertible Note | Accrued expenses

June 2017 Convertible Note | Current liabilities

4,548

6,180

Fair value of derivative liability due to repayment of mandatory default

2,155,000

$ 15,000

Fair value of derivative liability due to interest rate increase feature

5,000

15,000

$ 11,000

$ 20,000

540,684

Principal and interest paid on debt

509,000

1,451,454

$ 366,098

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Debt and Warrants - Convertible Notes and Long-term Debt (Details)		1 Months Ended						3 Months Ended		12 Months Ended
	Mar. 16, 2018 USD ($) shares	Apr. 30, 2018 shares	Mar. 31, 2018 USD ($) $ / shares shares	Jul. 31, 2017 USD ($) Lender	Mar. 31, 2017 USD ($) Lender shares	Dec. 31, 2016 USD ($) $ / shares Lender	Jun. 30, 2016 shares	Mar. 31, 2018 USD ($) $ / shares shares	Mar. 31, 2017 USD ($) Lender shares	Dec. 31, 2017 USD ($) $ / shares	Jun. 30, 2017 USD ($)	Mar. 01, 2016	Aug. 31, 2015 USD ($)
Debt and Warrants
Interest Payable			$ 15,489					$ 15,489
Shares issued (in shares) \| shares		2,034,082	4,285,423				2,444,486	6,000,000
Shares issued to creditors \| shares			270,270					270,270
Interest and amortization								$ 249,666
Debt appreciation amortization								107,167
Interest excluding appreciation amortization								142,529
Loan and security agreement
Debt and Warrants
Interest rate (as a percent)												9.90%
Unamortized note discount										$ 6,615			$ 134,433
Interest and amortization								99,300	$ 175,633
Debt appreciation amortization								$ (20,779)	(11,678)
Effective interest rate													15.00%
Napo
Debt and Warrants
Strike price (in dollars per share) \| $ / shares			$ 0.56					$ 0.56
Fair value of warrants			$ 630,859					$ 630,859
Napo \| Convertible promissory notes, December 2016
Debt and Warrants
Notes payable						$ 2,500,000
Fair value of notes						$ 11,161,000
Strike price (in dollars per share) \| $ / shares						$ 0.5893
Term (in years)						2 years 5 months 1 day
Conversion price (in dollars per share) \| $ / shares						$ 0.925
Volatility (as a percent)						115.00%
Risk-free interest rate (as a percent)						1.41%
Number of lenders \| Lender						3
Proceeds from issuance of convertible debt				$ 6,000,000		$ 2,000,000
Unamortized note discount						$ 500,000
Revised principal value of debt											$ 2,625,338
Annual percentage of conversion						33.00%
Difference between the fair value of the notes and the principal balance						$ 1,035,661
Amortization period of such difference amount						29 months
Contra interest expenses						$ 178,562
Interest Payable			534,775					534,775
Debt legal fee	$ 169,950
Shares issued (in shares) \| shares	4,285,423
Napo \| Convertible promissory notes, December 2016 \| Convertible Long-term Debt
Debt and Warrants
Unamortized note discount										10,982,438
Unamortized balance of notes payable			$ 10,875,300					10,875,300
Napo \| Convertible promissory notes, December 2016 \| Accrued interest
Debt and Warrants
Accrued interest on notes payable								$ 163,670		$ 448,779
Napo \| Convertible note purchase agreement
Debt and Warrants
Notes payable						$ 12,500,000
Interest rate (as a percent)				10.00%
Debt instrument, frequency of periodic payment				six-month
Accrued interest capitalized to principal of debt											$ 125,338
Napo \| Exchangeable note purchase agreement
Debt and Warrants
Notes payable					$ 1,312,500				1,312,500
Value of each tranche					525,000				525,000
Face amount of each tranche					$ 656,250				$ 656,250
Interest rate (as a percent)					3.00%				3.00%
Maximum number of shares issuable under exchange \| shares					2,343,752				2,343,752
Fair value of notes					$ 1,312,500				$ 1,312,500
Accrued interest on notes payable					$ 29,774
Strike price (in dollars per share) \| $ / shares			$ 0.5893					$ 0.5893
Conversion price (in dollars per share) \| $ / shares			$ 0.5600					$ 0.5600		$ 0.56
Number of lenders \| Lender					2				2
Napo \| Convertible promissory notes, July 2017
Debt and Warrants
Notes payable				$ 7,500,000
Number of lenders \| Lender				4
Unamortized note discount				$ 1,500,000
Napo \| Tranche 1 \| Exchangeable note purchase agreement
Debt and Warrants
Term (in years)								4 months 2 days
Volatility (as a percent)								70.00%
Risk-free interest rate (as a percent)								1.09%
Napo \| Tranche 2 \| Exchangeable note purchase agreement
Debt and Warrants
Term (in years)								5 months 1 day
Volatility (as a percent)								100.00%
Risk-free interest rate (as a percent)								1.13%

Debt and Warrants - Amendment to Note Purchase Agreement and Notes (Details) - USD ($)

1 Months Ended

3 Months Ended

12 Months Ended

Mar. 23, 2018

Feb. 16, 2018

Dec. 31, 2017

Mar. 31, 2018

Mar. 31, 2017

Dec. 31, 2017

Jan. 31, 2018

Dec. 08, 2017

Nov. 30, 2017

Dec. 31, 2016

$ (207,713)

$ 11,000

^[1]

$ 15,000

$ 11,000

^[1]

Shares issued to creditors

$ 111,841

^[1]

$ 0

$ 111,841

^[1]

270,270

Napo

$ 0.56

Minimum | Napo

1 year 5 months 1 day

75.07%

1.28%

Maximum | Napo

8 years 5 months 1 day

110.03%

2.14%

Conversion price (in dollars per share)

$ 0.20

$ 0.21

$ 0.14

1 month 10 days

288.16%

1.69%

Conversion option liability | Minimum

0.00%

1 month 17 days

86.29%

Conversion option liability | Maximum

1.28%

3 months

160.78%

Second Amendment to Note Purchase Agreement and Notes | Napo

1.39%

Accrued interest on notes payable

$ 18,063

Shares issued to creditors

3,783,444

Second Amendment to Note Purchase Agreement and Notes | Conversion option liability | Napo

$ 435,950

Principal paid

$ 735,000

Interest paid

$ 20,699.38

$ 0.21

1 month 10 days

288.16%

1.69%

Increase to the fair value of the conversion option liability

0.00%

$ 174,754

Conversion option liability written off

$ 286,595

Convertible note purchase agreement | Napo

Convertible note purchase agreement | First Amendment to Note Purchase Agreement and Notes

$ 12,500,000

Percent of increase in the principal amount

12.00%

Conversion price (in dollars per share)

$ 0.20

$ 0.56

Issuance of common stock in exchange for services (in shares)

2,492,084

Partial redemption of convertible notes

$ 299,050

1,170,950

$ 1,170,950

157,500

$ 111,841

$ 0.14

0.00%

Convertible note purchase agreement | First Amendment to Note Purchase Agreement and Notes | Accrued expenses

$ 1,170,950

Accrued interest on notes payable

$ 29,774

Convertible note purchase agreement | First Amendment to Note Purchase Agreement and Notes | Minimum

1 month 17 days

86.29%

Convertible note purchase agreement | First Amendment to Note Purchase Agreement and Notes | Maximum

1.28%

3 months

160.78%

Promissory Note, December 08, 2017 | Securities Purchase Agreement

1.39%

$ 2,155,000

$ 1,587,500

$ 462,500

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Debt and Warrants - Long-term Debt (Details) - USD ($)

1 Months Ended

3 Months Ended

4 Months Ended

Aug. 01, 2018

Mar. 23, 2018

Jul. 07, 2017

Apr. 21, 2016

Aug. 31, 2015

Mar. 31, 2018

Oct. 31, 2017

Mar. 31, 2017

Aug. 31, 2016

Dec. 31, 2017

Jul. 31, 2017

Jun. 29, 2017

Dec. 31, 2016

Jul. 31, 2016

Mar. 01, 2016

Aug. 18, 2015

Current portion of long-term debt

$ 0

$ 1,609,244

^[1]

Long-term debt, net of discount

10,875,300

10,982,437

^[1]

(107,167)

Interest payable on long-term debt

249,666

9,422

Stand-by line of credit

$ 8,000,000

Interest-only payments, term

4 months

February 2015 Convertible Note

$ 21,192

239,169

^[1]

4,438

$ 4,438

Convertible promissory notes, December 2016 | Napo

12.00%

$ (500,000)

$ 500,000

$ (425,000)

18,864

118,923

8.00%

June 2017 Convertible Note | Interest Expense

$ 425,000

Convertible promissory notes, July 2017 | Napo

118,923

$ (1,500,000)

Convertible note purchase agreement | Napo

$ 1,500,000

Exchangeable note purchase agreement | Napo

10.00%

Loan and security agreement

3.00%

Debt and unpaid accrued end-of-term payment

1,636,639

Unamortized debt issuance costs

$ (134,433)

(6,615)

(20,780)

Current portion of long-term debt

1,609,244

1,609,244

19,344

$ 78,861

Accretion of end-of-term payment

20,779

11,678

52,561

48,655

Accretion of debt issuance costs

6,616

36,439

$ 99,300

$ 175,633

Stand-by line of credit

8,000,000

Initial loan commitment

6,000,000

Additional borrowing capacity contingent on achievement of milestones

4,500,000

$ 2,000,000

Term of agreement

3 years

9.90%

Effective interest rate

15.00%

Prior notification period required for pre-payment of principal and accrued interest (in days)

$ 134,433

$ 6,615

5 days

Repayment of loan from restricted cash

$ 1,500,000

Loan and security agreement | Forecast

Balloon amount payable on August 1, 2018

$ 600,000

Loan and security agreement | Prepayment during the first twelve months member

Prepayment charge during first twelve months of loan when a minimum cash balance is required as a percent of minimum cash balance

2.00%

Prepayment charge during first twelve months of loan when a minimum cash balance is required as a percent of difference between amount being prepaid and minimum cash balance

3.00%

Prepayment charge during first twelve months of loan when no minimum cash balance is required as a percent of amount being prepaid

3.00%

Loan and security agreement | Prepayment after the first twelve months member

Prepayment charge as a percent of amount being prepaid

1.00%

Third Amendment

Repayment of loan from restricted cash

$ 1,000,000

Interest-only payments, term

3 months

Differences in cash flow (as a percent)

$ 500,000

10.00%

Principal paid

$ 689,345

Interest paid

4,471

Cash proceeds

$ 600,000

[1]	The condensed balance sheet at December 31, 2017 is derived from the audited financial statements at that date included in the Company's Form 10-K filed with the Securities and Exchange Commission on April 9, 2018.

Debt and Warrants - Notes Payable(Details) - USD ($)	3 Months Ended
Debt and Warrants - Notes Payable(Details) - USD ($)	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017
Short-term debt
Convertible notes payable, Gross	$ 11,708,885		$ 13,916,478
Less: unamortized debt discount and debt issuance costs	(142,902)		(261,826)
Net convertible notes payable obligation	11,565,983		13,654,652
Accretion of debt discount	(107,167)
Total interest expense on convertible debt	230,053	$ 4,438
Interest payable	342,498		659,961
Short-term notes payable
Short-term debt
Convertible notes payable, Gross	4,918,750		1,587,500
Less: unamortized debt discount and debt issuance costs	(1,262,651)		(446,347)
Net convertible notes payable obligation	3,656,099		1,141,153
Nominal interest	49,659
Accretion of debt discount	204,946
Total interest expense on convertible debt	254,605
Interest payable	57,793		8,134
December 2017 note payable \| Short-term notes payable
Short-term debt
Convertible notes payable, Gross	1,587,500		$ 1,587,500
February 2018 note payable \| Short-term notes payable
Short-term debt
Convertible notes payable, Gross	2,240,909
March 2018 note payable \| Short-term notes payable
Short-term debt
Convertible notes payable, Gross	$ 1,090,341

Debt and Warrants - Securities Purchase Agreement (Details) - USD ($)

3 Months Ended

Mar. 21, 2018

Feb. 26, 2018

Jan. 31, 2018

Dec. 08, 2017

Mar. 31, 2018

Mar. 31, 2017

Dec. 31, 2017

Jun. 29, 2017

$ 690,683

$ 2,672,215

^[1]

15,489

602,022

$ 180,072

(107,167)

$ 2,155,000

$ 425,000

8.00%

121,018

118,228

June 2017 Convertible Note | Accrued expenses

118,923

June 2017 Convertible Note | Current liabilities

4,548

6,180

2,155,000

540,684

509,000

June 2017 Convertible Note | Interest Expense

366,098

18,864

March 2018 note payable | Redemption Start Condition is satisfied by April 1, 2018

118,923

Minimum amount of equity required under condition

12,000,000

March 2018 note payable | Chicago Venture Partners, L.P. | Redemption Start Condition is satisfied by April 1, 2018

Maximum aggregate redemption amount

500,000

Securities Purchase Agreement

Maximum gross cash proceeds not to issue any variable securities under the securities purchase agreement

1,000,000

Maximum amount not to incur any debt other than in the ordinary course of business under the security purchase agreement

10,000

Securities Purchase Agreement | Redemption Start Condition is satisfied by April 1, 2018

Maximum aggregate redemption amount

$ 500,000

Securities Purchase Agreement | Chicago Venture Partners, L.P.

Percentage of rights to purchase debt under term loan

100.00%

Securities Purchase Agreement | Promissory Note, December 08, 2017

$ 2,155,000

$ 1,587,500

Aggregate purchase price

1,100,000

$ 462,500

8.00%

$ 1,301,783

487,500

Maximum redemption amount per month during first six month period

$ 40,364

$ 8,333

350,000

Maximum redemption amount per month, thereafter

$ 500,000

Transaction expenses

$ 25,000

Securities Purchase Agreement | Promissory Note, December 08, 2017 | Current liabilities

Securities Purchase Agreement | Promissory Note, December 08, 2017 | Interest Expense

201,783

32,230

Securities Purchase Agreement | Promissory Note, December 08, 2017 | Chicago Venture Partners, L.P. | Redemption Start Condition is satisfied by April 1, 2018

160,630

Securities Purchase Agreement | February 2018 note payable

1,587,500

$ 2,240,909

$ 655,909

8.00%

$ 1,599,217

680,909

Proceeds from issuance of notes payable, net

39,217

1,560,000

Minimum amount of equity raised to repay the Notes payable

12,000,000

Securities Purchase Agreement | February 2018 note payable | Current liabilities

Securities Purchase Agreement | February 2018 note payable | Interest Expense

15,489

15,489

Securities Purchase Agreement | February 2018 note payable | Chicago Venture Partners, L.P.

39,217

Securities Purchase Agreement | June 2017 Convertible Note | Chicago Venture Partners, L.P. | Redemption Start Condition is satisfied by April 1, 2018

Transaction expenses

$ 25,000

Securities Purchase Agreement | March 2018 note payable | Chicago Venture Partners, L.P.

$ 2,155,000

$ 1,090,341

$ 315,341