Jaguar Animal Health Field Study Confirms Beneficial Effect of Neonorm on Average Daily Weight in Calves
Results Support Study to Investigate Potential Prebiotic Effect on Calf Gut Microbiome
On average, each calf receiving Neonorm treatment in the recent field
study gained approximately 1.2 kilograms more than the placebo-treated
calves during the preweaning period. “This data confirms the findings of
the challenge study. Based on current industry cost standards, we
estimate that Neonorm could save approximately
Both studies were conducted by Dr.
The gut microbiota of dairy calves is known to influence major aspects of postnatal life, such as development of the immune system and potentially altering the host’s physiology. Low incidence of diseases and efficient growth in preweaned dairy calves are highly important for an optimal post-weaning performance.
Jaguar is now supporting work in Dr. Bicalho’s lab to use Next Generation Sequencing to characterize the fecal microbiota of diarrheic from the challenge study to identify possible relationships between Neonorm treatment and the altering of intestinal microbiota profiles, and a contributing explanation for improved weight gain in the animals.
“It’s really exciting to explore this new frontier in gut biome research
pioneered by Dr. Bicalho, supported by the results of our recently
completed field study and previously completed challenge study. The
mechanism would supplement and is potentially synergistic with the
anti-secretory benefit of Neonorm Calf. There are recent data in humans
published in the
These are results from the first of four field studies involving a total of approximately 700 preweaned dairy calves conducted to support Jaguar’s commercial launch of Neonorm.
About Neonorm Calf
Neonorm Calf is an enteric-coated tablet designed to be orally
administered to preweaned dairy calves twice daily for three days. It
has been formulated and clinically tested to specifically address the
normalization of stool formation and ion and water flow in the
intestinal lumen of newborn dairy calves. The product acts locally in
the gut and is minimally absorbed systemically. It does not alter
gastrointestinal motility, and, to date, has shown no significant
effects on normally functioning intestinal ion channels and electrolyte
or fluid transport, nor shown any side effects different from placebo.
As a result, stool formation is normalized in a short period of time,
weight loss is mitigated, and supportive care costs and rehydration
therapies such as oral rehydration solution, or ORS, are reduced.
Neonorm has not been evaluated by the
For more information, please visit www.jaguaranimalhealth.com.
Certain statements in this press release constitute “forward-looking statements.” These include statements regarding the estimated savings per treated dairy calf presenting with scours provided by Neonorm™ Calf, the potential relationships between treatment with Neonorm™ Calf and altering the intestinal microbiota profiles, and a contributing explanation for improved weight gain in the animals, and potential synergies with the anti-secretory benefit of Neonorm™ Calf. In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “aim,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions. The forward-looking statements in this release are only predictions. Jaguar has based these forward-looking statements largely on its current expectations and projections about future events. These forward-looking statements speak only as of the date of this release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond Jaguar’s control. Except as required by applicable law, Jaguar does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.
Jaguar Animal Health
Peter Hodge, 203-539-0423