Jaguar Animal Health Initiates University Pilot Safety Study to Evaluate Use of Crofelemer for the Treatment of Diarrhea Associated with Acute Colitis in Horses
Colitis is defined as inflammation of the large bowel, and the condition can affect adult horses as well as foals. Acute colitis can cause sudden, massive fluid loss and severe electrolyte imbalances that can result in death in a matter of hours. Acute colitis often occurs when Salmonella and Clostridium difficile, bacteria that are normally present in the gut, are activated by stress, or when the bacteria Neorickettsia risticii is ingested, causing Potomac Horse Fever, which has been studied as a secretory type of diarrhea by third parties. Stress (e.g., shipping, changes in daily routines, illness, hospitalization, racing), recent diet changes, recent antimicrobial administration, and non-steroidal anti-inflammatory drug therapy can also put horses at risk for acute colitis.
“Colitis can affect thousands of horses in
In this pilot safety study, three horses will be treated with four consecutive, three-day cycles of escalating dose levels of a crofelemer paste administered orally twice or four times per day. Clinical observations and adverse events will be evaluated for dose-limiting toxicity after each dose level.
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Certain statements in this press release constitute “forward-looking statements.” These include statements regarding Jaguar’s plan to launch an equine formulation of crofelemer for treatment of acute colitis in horses, the Company’s intention to develop species-specific formulations of Neonorm™ in additional target species, and the Company’s plan to develop formulations of Canalevia™ for cats, horses and dogs. In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “aim,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions. The forward-looking statements in this release are only predictions. Jaguar has based these forward-looking statements largely on its current expectations and projections about future events. These forward-looking statements speak only as of the date of this release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond Jaguar’s control. Except as required by applicable law, Jaguar does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.