Jaguar Health and Napo Pharmaceuticals Provide Key Findings from Cancer-related Diarrhea Abstracts Submitted to ASCO for June 2021 Annual Meeting
Abstract accepted for poster presentation: The impact of cancer-related diarrhea on changes in cancer therapy patterns: Real world evidence
- Poster Session: Symptoms and Survivorship
- Background: Study of the impact that CRD has on cancer therapy and treatment patterns, including persistence, discontinuation, adherence, and switching of chemotherapy and targeted therapies in patients with and without CRD.
- Conclusion: Patients with CRD were 40% more likely to discontinue the chemotherapy or targeted therapy than patients without CRD. The persistence of index cancer therapy and time to switch were also lower for patients with CRD. Strategies to control CRD and continue cancer therapy are urgently needed.
- Lead author:
Pablo C. Okhuysen, M.D., Professor of Medicine, Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine, at the University of Texas, MD Anderson Cancer Centerin Houston, Texas. Additional authors include Lee Schwartzberg, M.D., FACP and Eric Roeland, M.D., FAAHPM.
Abstract accepted for online publication: Characterizing unplanned resource utilization associated with cancer-related diarrhea
- Background: In clinical oncology practice, diarrhea is a very common and severe side effect of cancer treatments including from radiotherapy, chemotherapy, and targeted therapies. CRD leads to increased healthcare resource consumption due to unscheduled outpatient visits, and increased hospital stays requiring intensive supportive care measures. We evaluated CRD patients receiving chemotherapy, targeted therapy, or both, requiring emergency department, physician office visits, hospitalizations, and length of stay compared to a matched cohort of non-CRD patients.
- Conclusion: Patients with CRD used significantly more resources, including outpatient services, ED visits, and hospitalizations. Effective prevention of CRD remains an unmet strategy to reduce the overall cost of cancer care.
- Lead author:
Lee Schwartzberg, M.D., FACP, a renowned medical oncologist and hematologist who serves as Executive Director of West Cancer Centerin Memphis, Tennessee. Additional authors include Eric Roeland, M.D., FAAHPM and Pablo C. Okhuysen, M.D.
Abstract accepted for online publication: Healthcare utilization and costs associated with cancer-related diarrhea
- Background: Diarrhea is a common toxicity of cancer treatments, including radiotherapy, chemotherapy, and/or targeted therapies. CRD leads to increased healthcare utilization and cost. This study evaluated the all-cause and CRD-specific healthcare utilization and cost of patients with CRD compared to a matched non-CRD cohort.
- Conclusion: Our findings show that patients with CRD had nearly 2.9 times higher all-cause total cost than patients without CRD after adjusting for covariates. Prevention of CRD may result in a significant reduction in cancer-treatment cost.
- Lead author:
Eric Roeland, M.D., FAAHPM, Attending Physician, Center for Palliative Care, Harvard Medical School. Additional authors include Pablo C. Okhuysen, M.D. and Lee Schwartzberg, M.D., FACP.
All three authors serve as key opinion leaders/consultants to Napo.
ASCO received more than 5,400 abstracts for the 2021 ASCO Annual Meeting, which were reviewed by the Society's Scientific Program Committee and ASCO Leadership. Additional information about the 2021 ASCO Annual Meeting can be found on the ASCO website: https://meetings.asco.org/am/attend.
As previously announced, Napo's pivotal Phase 3 clinical trial of crofelemer (Mytesi®) for prophylaxis of diarrhea in adult cancer patients receiving targeted therapy was initiated in
Mytesi® (crofelemer) is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Mytesi® is not indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before starting Mytesi®. If infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not receive the appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a rate greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and increased bilirubin (3.1%).
More information and complete Prescribing Information are available at Mytesi.com. Crofelemer, the active ingredient in Mytesi®, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon Rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure a high degree of quality and ecological integrity.
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