News Release Details
News Release Details
Jaguar Health Hosts Symposium on the Management of Cancer Therapy-related Diarrhea
The symposium also discussed the need for prophylaxis of diarrhea in cancer patients as a paradigm-shift to mitigate the impact of CTD on activities of daily living (ADL), cancer therapy dose reductions, and/or discontinuations and overall improvement in the quality of life (QOL) of cancer patients receiving targeted therapy with or without standard chemotherapy. Additionally, the panel discussed the recently published results of a recent prophylactic study in breast cancer patients receiving trastuzumab, pertuzumab and a taxane with or without crofelemer (HALT-D) and the features of the ongoing phase 3 pivotal clinical study evaluating the safety and efficacy of crofelemer as prophylaxis for CTD in adult patients with solid tumors receiving targeted therapy with or without standard chemotherapy (Protocol NP303-102;
"We were very pleased with the level of participation in this first ever symposium to discuss the management of CTD and the neglected burden of CTD on cancer patients," said
Speakers and panelists at the symposium included faculty members from academic institutions and private clinics as well as Napo's clinical leadership team:
Pablo C. Okhuysen, MD: Professor of Medicine, Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine, University of Texas, MD Anderson Cancer Centerin Houston, TX. Lee Schwartzberg, MD, FACP: Leading breast cancer medical oncologist and hematologist who serves as Chief of Medical Oncology and Hematology at the Renown Health-William N. Pennington Cancer Institutein Reno, NV; formerly Executive Director, West Clinic, Memphis, TN. Eric Roeland, MD, FAAHPM: Assistant Professor of Medicine, Division of Hematology/Medical Oncology, School of Medicine, Oregon Health & Science University; formerly Assistant Professor of Medicine, Massachusetts General Hospital, Harvard Medical School.
- James T. D'Olimpio, MD, FACP, FAAHPM: Principal Investigator/Consultant,
Clinical Research Alliance, Westbury, NY; formerly Director of Supportive Oncology/Cancer Pain and Symptom Management at North Shore University Hospital, and Assistant Professor of Medicine at Hofstra/North Shore-LIJ School of Medicine. Paula Pohlmann, MD, PhD: Associate Professor, MD Anderson Cancer Center. Pravin Chaturvedi, PhD: Napo Pharmaceuticals'and Jaguar Health'sChair of Scientific Advisory Boardand Chief Scientific Officer. Darlene Horton, MD: Napo Pharmaceuticals'Chief Medical Officer. Allison Shrier, MD: Napo Pharmaceuticals'Vice President of Clinical Research and Medical Affairs.
About Cancer Therapy-related Diarrhea
A significant proportion of patients undergoing cancer therapy experience diarrhea, and diarrhea has the potential to cause dehydration, potential infections, and non-adherence to treatment in this population. Novel "targeted cancer therapy" agents, such as epidermal growth factor receptor (EGFR) antibodies and tyrosine kinase inhibitors (TKIs), with or without cycle chemotherapy agents, may cause increased electrolyte and fluid content in the gut lumen, which results in passage of loose/watery stools (i.e., diarrhea). Diarrhea has been reported as one of the most common side effects of TKIs and may result in cancer therapy drug holidays or reductions from therapeutic dose, potentially impacting patient outcome. Diarrhea is also a common side effect of some approved CDK 4/6 inhibitors.
Crofelemer is a novel, oral plant-based medicine purified from the red bark sap, also referred to as "dragon's blood," of the medicinal Croton lechleri tree in the Amazon Rainforest.
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