Jaguar Neonorm Foal Study Accepted for Publication in Veterinary Journal
Neonorm™ Foal, one of Jaguar’s lead non-prescription
products, is a non-drug anti-diarrheal for newborn horses in
orally-administered paste form. Dr.
The study objective was to evaluate the safety, tolerability, and efficacy of Neonorm™ Foal for treatment of foals suffering from secretory or watery diarrhea. Sixty foals participated in the study, which consisted of a 72-hour treatment period followed by an observation period. The treated animals received Neonorm™ Foal in combination with a third-party probiotic.
Each participating foal was placed into one of three groups: a group that received treatment twice a day (the BID group), a group that received treatment four times a day (the QID group), and a placebo-treated group. Physicals, ultrasounds and the collection of blood samples took place at intervals throughout the study. Fecal scoring was conducted in conjunction with the dosing times during the treatment period and followed by twice daily thereafter until the end of the observation period.
The percentage of responders from 0-72 hours was greater in the IVP BID group (68%) than in the placebo group (35%) with a p value of 0.03. The percentage of responders from 0-96 hours was also found to be greater in IVP BID group (79%) when compared to the placebo group (47%) with a p value of 0.03. From 0-120 hours, the percentage of responders in the IVP QID group was 84% versus 53% in the placebo group, which was found to be significant with a p value of 0.04.
For the subset of foals with a baseline fecal score of 4 (indicating severe watery diarrhea with no particulate matter visible or no diarrhea seen but watery staining of the tail, perineum or walls evident), the percentage of responders from 0-96 hours was found to be significantly different (p = 0.02) between the IVP BID (85%) and placebo (39%) groups. For the interval from 0-120 hours, the IVP QID group (94%) was found to be significantly different (p = 0.02) from the placebo group (46%).
“We’re thrilled that this study has been accepted for publication by Analecta
Veterinaria. Jaguar’s Neonorm™ and crofelemer products,
which are both derived from the sustainably harvested Croton lechleri
tree, act at the same last step in a physiological pathway generally
present in mammals. Clinical research investigating this unique
Mechanism of Action have provided efficacy results with significance in
people, calves and dogs in addition to horses. The Neonorm™
Foal study results support our belief that the first-in-class
anti-secretory properties of Neonorm™ will redefine the
standard of care for management of diarrhea, gut health, and the
normalization of hydration in foals and underscores our ongoing
commitment to total equine gut health,” stated
Dr. McAuliffe commented, “Word spread very quickly in
Diarrhea is one of the most common clinical complaints in foals, especially within the first 30 days of life, and to Jaguar’s knowledge there are currently no commercially available products with anti-secretory properties for foals. The crippling effects of dehydration that often occur as a result of secretory diarrhea in foals can manifest quickly, precipitate adverse health effects and result in death.
For more information, please visit www.napopharma.com.
For more information about Jaguar, please visit www.jaguaranimalhealth.com.
Certain statements in this press release constitute “forward-looking statements.” These include statements regarding the proposed merger between Jaguar and Napo, Jaguar’s intention to develop species-specific formulations of Neonorm™ in additional target species, and the Company’s plan to develop formulations of Canalevia™ for cats, horses and dogs. In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “aim,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions. The forward-looking statements in this release are only predictions. Jaguar has based these forward-looking statements largely on its current expectations and projections about future events. These forward-looking statements speak only as of the date of this release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond Jaguar’s control. Except as required by applicable law, Jaguar does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.
KCSA Strategic Communications
Garth Russell, 212-896-1250